An unusual case of splenomegaly and increased lactate dehydrogenase heralding acute myeloid leukemia with eosinophilia and RUNX1-MECOM fusion transcripts
| Autor: | Valeria Fantuzzi, Leonardo Potenza, Ambra Paolini, Mario Luppi, Vincenzo Nasillo, Monica Morselli, Fabio Forghieri, Sara Bigliardi, Laura Faglioni, Andrea Messerotti |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty MECOM Myeloproliferative neoplasm Case Report lcsh:RC254-282 Acute myeloid leukemia Eosinophilia RUNX1–MECOM Splenomegaly t(3 21)(q26 q22) chemistry.chemical_compound hemic and lymphatic diseases Increased lactate dehydrogenase Medicine Myocardial infarction Unusual case business.industry Myeloid leukemia Hematology medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Oncology RUNX1 chemistry Immunology medicine.symptom business |
| Zdroj: | Leukemia Research Reports, Vol 3, Iss 2, Pp 83-85 (2014) Leukemia Research Reports |
| Popis: | We report the first case of acute myeloid leukemia (AML) with RUNX1–MECOM fusion transcripts, showing marked eosinophilia. A 63-year old man admitted in August 2013, had previously been observed in April 2013, because of persisting homogeneous splenomegaly and increased LDH, which were initially attributed to both minor β-thalassemia and previous acute myocardial infarction. However, based upon the retrospective analysis of clinical features combined with the documentation of both JAK2 V617F and c-KIT D816V mutations at AML diagnosis, an aggressive leukemic transformation with eosinophilia of a previously unrecognized myeloproliferative neoplasm, rather than the occurrence of de novo AML, may be hypothesized. Highlights • We report the first case of AML with RUNX1–MECOM fusion transcripts and eosinophilia. • JAK2 V617F and c-KIT D816V mutations have been concurrently observed. • Leukemic transformation of a previously unrecognized MPN may be hypothesized. |
| Databáze: | OpenAIRE |
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