A marine microbiome antifungal targets urgent-threat drug-resistant fungi
| Autor: | Jeff S. Piotrowski, Weiping Tang, Justin Nelson, Hiram Sanchez, Fan Zhang, Marc G. Chevrette, Spencer S. Ericksen, Tim S. Bugni, Gene E. Ananiev, Cameron R. Currie, Jen Fossen, David R. Andes, Le Guo, Kenneth J. Barns, Changgui Zhao, Miao Zhao, Ilia A. Guzei, Anjon Audhya, Shaurya Chanana, Scott R. Rajski, Jian Peng, Doug R. Braun |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Antifungal
Antifungal Agents medicine.drug_class Antifungal drugs Antifungal drug Drug resistance Micromonospora Safety index Article Microbiology Fungal Proteins Mice Drug Resistance Multiple Fungal medicine Humans Animals Benzopyrans Candidiasis Invasive Microbiome Urochordata Phospholipid Transfer Proteins Mode of action Candida Multidisciplinary Microbiota Fungi Isoquinolines Disease Models Animal Candida auris Pharmaceutical Preparations |
| Zdroj: | Science |
| ISSN: | 1095-9203 |
| Popis: | Prospecting for antifungal molecules Marine bacteria produce a plethora of natural products that often have unusual chemical structures and corresponding reactivity, which sometimes translate into a valuable biological function. Zhang et al. used a metabolomic screen to zero in on microbial strains from the microbiome of a sea squirt that produces a high diversity of chemical structures. They then screened these molecules for inhibition of fungi (see the Perspective by Cowen). A polycyclic molecule dubbed turbinmicin possessed potent antifungal activity against the multidrug-resistant fungal pathogens Candida auris and Aspergillus fumigatus . Preliminary mechanism-of-action and mouse toxicity studies suggest that this molecule works though a fungus-specific pathway and is well tolerated at therapeutic doses. Science , this issue p. 974 ; see also p. 906 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |