Two-years of home based functional electrical stimulation recovers epidermis from atrophy and flattening after years of complete Conus-Cauda Syndrome
| Autor: | Barbara Ravara, Diego Guidolin, Helmut Kern, Stefan Loefler, Ugo Carraro, Raffaele De Caro, Andrea Porzionato, Sandra Zampieri, Wolfgang Jurecka, Giovanna Albertin, Amber Pond, Christian Hofer, Anna Rambaldo, Mauro Alaibac |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Biopsy Observational Study Stimulation Electric Stimulation Therapy Thigh Skin Diseases 03 medical and health sciences denervated-degenerating muscle Young Adult 0302 clinical medicine Atrophy medicine h-bFES Functional electrical stimulation Humans 030212 general & internal medicine Epidermis Middle Aged Skin Spinal Cord Injuries Syndrome Spinal Cord Anterior compartment of thigh Spinal cord injury long-term effects skin biopsy integumentary system business.industry General Medicine Anatomy medicine.disease Spinal cord spinal cord injury Dermal papillae medicine.anatomical_structure 030220 oncology & carcinogenesis epidermis morphometry business Research Article |
| Zdroj: | Medicine |
| Popis: | To evaluate progression of skin atrophy during 8 years of complete Conus-Cauda Syndrome and its recovery after 2 years of surface Functional Electrical Stimulation a cohort study was organized and implemented. Functional assessments, tissue biopsies, and follow-up were performed at the Wilhelminenspital, Vienna, Austria; skin histology and immunohistochemistry at the University of Padova, Italy on 13 spinal cord injury persons suffering up to 10 years of complete conus/cauda syndrome. Skin biopsies (n. 52) of both legs were analyzed before and after 2 years of home-based Functional Electrical Stimulation delivered by large anatomically shaped surface electrodes placed on the skin of the anterior thigh. Using quantitative histology we analyzed: 1. Epidermis atrophy by thickness and by area; 2. Skin flattening by computing papillae per mm and Interdigitation Index of dermal-epidermal junctions; 3. Presence of Langerhans cells. Linear regression analyses show that epidermal atrophy and flattening worsen with increasing years post- spinal cord injury and that 2 years of skin electrostimulation by large anatomically shaped electrodes reverses skin changes (pre-functional Electrical Stimulation vs post-functional Electrical Stimulation: thickness 39%, P |
| Databáze: | OpenAIRE |
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