Inflammatory monocyte/macrophage modulation by liposome-entrapped spironolactone ameliorates acute lung injury in mice

Autor: Xin Zhang, Yong Qiang Ma, Yu-Ming Li, Yi Dan Zhang, Xin Zhou, Lu Qing Wei, Zhuoli Zhang, Peizhong Peter Wang, Guo An Xiang, Mei Ping Zhang, Cheng Cheng Su, Li Zhang, Zhi Chun Lin, Wen Jie Ji
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Pulmonary Fibrosis
Medical Biotechnology
Anti-Inflammatory Agents
Medicine (miscellaneous)
02 engineering and technology
Spironolactone
Pharmacology
Inbred C57BL
Monocytes
Mice
chemistry.chemical_compound
Mineralocorticoid receptor
Oral administration
Fibrosis
Pulmonary fibrosis
Nanotechnology
General Materials Science
Acute Respiratory Distress Syndrome
Lung
Mineralocorticoid Receptor Antagonists
Liposome
Cell Polarity
respiratory system
021001 nanoscience & nanotechnology
liposome
0210 nano-technology
Research Article
Physical Chemistry (incl. Structural)
Acute Lung Injury
Biomedical Engineering
Bioengineering
Development
Lung injury
Alveolar
Bleomycin
03 medical and health sciences
Rare Diseases
Macrophages
Alveolar
medicine
Animals
Humans
Particle Size
Nanoscience & Nanotechnology
business.industry
Macrophages
medicine.disease
Mice
Inbred C57BL
030104 developmental biology
chemistry
Liposomes
Immunology
business
Zdroj: Nanomedicine (London, England), vol 11, iss 11
ISSN: 1748-6963
1743-5889
Popis: Aim: To examine the therapeutic/preventive potential of liposome-encapsulated spironolactone (SP; Lipo-SP) for acute lung injury (ALI) and fibrosis. Materials & methods: Lipo-SP was prepared by the film-ultrasonic method, and physicochemical and pharmacokinetic characterized for oral administration (10 and 20 mg/kg for SP-loaded liposome; 20 mg/kg for free SP) in a mouse model bleomycin-induced ALI. Results: Lipo-SP enhanced bioavailability of SP with significant amelioration in lung pathology. Mechanistically, SP-mediated mineralocorticoid receptor antagonism contributes to inflammatory monocyte/macrophage modulation via an inhibitory effect on Ly6Chi monocytosis-directed M2 polarization of alveolar macrophages. Moreover, Lipo-SP at lower dose (10 mg/kg) exhibited more improvement in body weight gain. Conclusion: Our data highlight Lipo-SP as a promising approach with therapeutic/preventive potential for ALI and fibrosis.
Databáze: OpenAIRE
Externí odkaz: