Direct Arylation in the Presence of Palladium Pincer Complexes
| Autor: | Nerea Conde, Fátima Churruca, Raul SanMartin, María Teresa Herrero, Garazi Urgoitia |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmaceutical Science
chemistry.chemical_element Organic chemistry Review 010402 general chemistry 01 natural sciences Analytical Chemistry Catalysis QD241-441 Drug Discovery Physical and Theoretical Chemistry Reaction conditions 010405 organic chemistry Negishi coupling Intermolecular force direct arylation palladium Combinatorial chemistry 0104 chemical sciences Pincer movement Stille reaction chemistry Chemistry (miscellaneous) Molecular Medicine pincer complexes Palladium |
| Zdroj: | Addi. Archivo Digital para la Docencia y la Investigación instname Molecules, Vol 26, Iss 4385, p 4385 (2021) Addi: Archivo Digital para la Docencia y la Investigación Universidad del País Vasco Molecules |
| Popis: | Direct arylation is an atom-economical alternative to more established procedures such as Stille, Suzuki or Negishi arylation reactions. In comparison with other palladium sources and ligands, the use of palladium pincer complexes as catalysts or pre-catalysts for direct arylation has resulted in improved efficiency, higher reaction yields, and advantageous reaction conditions. In addition to a revision of the literature concerning intra- and intermolecular direct arylation reactions performed in the presence of palladium pincer complexes, the role of these remarkably active catalysts will also be discussed. This research was funded by the Basque Government (IT1405-19) and the Spanish Ministry of Economy and Competitiveness (CTQ2017-86630-P). |
| Databáze: | OpenAIRE |
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