| Autor: |
Nguyen Thu Anh, Vinh Dai Nguyen, Ha Viet Nguyen, Thach Ngoc Pham, Gregory J. Fox, Nam Tan Truong, Chung Thanh Le, Giang Linh Tran, Yen Ngoc Pham, Hoang Trung Vo, Thanh Trung Nguyen, Trang Dinh Van, Thao Thi Thanh Nguyen, Phuc Thanh Le, Brett G. Toelle, Than Huu Dao, Viet Quang Truong, Van Thi Cam Nguyen, Hien Thi Thu Le, Duyet Van Le, Thuy Thi Dang, Vinh Van Luu, Tasnim Hasan, Guy B. Marks |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| DOI: |
10.2139/ssrn.3781699 |
| Popis: |
Background: As a response to the coronavirus disease 2019 (COVID-19) pandemic, Vietnam enforced strict quarantine, contact tracing and physical distancing policies. By December 2020, this strategy resulted in one of the lowest numbers of individuals infected with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) cases globally. This study aimed to determine the prevalence of SARS-CoV-2 antibody positivity among high-risk populations in Vietnam. Methods: A prevalence survey was undertaken within four communities in northern and central Vietnam, where at least two COVID-19 cases had been confirmed. Participants were classified according to the location of exposure: household contacts, close contacts, community members, and healthcare workers (HCWs) responsible for treating COVID-19 cases. Participants completed a baseline questionnaire that evaluated exposure history. SARS-CoV-2 IgG antibodies were quantified using a commercially available assay. Results: 3056 community members and 149 health care workers provided consent to participate. Among enrolled community members, 27 (0·9%) were household contacts and 53 (1·7%) were close contacts. Serology was performed in 3034 individuals. Among 13 individuals who were seropositive (0·4%), five household contacts (5/27, 18·5%), one close contact (1/53, 1·9%), and seven community members (7/2954, 0·2%) had detectable SARS-CoV-2 antibodies. All HCWs were negative for SARS-CoV-2 antibodies. Participants were tested a median of 15·1 (interquartile range 14·9 to 15·2) weeks after exposure. Conclusion: The presence of SARS-CoV-2 antibodies in high-risk communities and healthcare workers was low in communities in Vietnam with known COVID-19 cases. The public health response to the COVID-19 pandemic in Vietnam has been effective in limiting community transmission of SARS-CoV-2. Funding Statement: This project was supported by a grant funded by the Australian Department of Foreign Affairs and Trade, awarded in conjunction with the Australian National Health and Medical Research Council (APP1153346). Declaration of Interests: None declared. Ethics Approval Statement: Ethical approval was obtained from the Human Research Ethics Committees of the University of Sydney (HREC 2020/415) and Biomedical Research Ethics Committee of the National Hospital for Tropical Diseases (No. 10/HDDD-NDTU and No. 18/HDDD-NDTU). Consent was documented electronically using a tablet computer. In accordance with local expectations, all COVID-19 patients and other participants were provided with monetary compensation for their participation, equivalent to approximately US$4·30 and US$2·20, respectively. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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