Association between Gasdermin A, Gasdermin B Polymorphisms and Allergic Rhinitis Amongst Jordanians
| Autor: | Malek Zihlif, Fatima M. Al-Akhras, Randa Naffa, Rami Alsalman, Tareq Mahafza, Tawfiq Froukh, Margaret Zuriekat |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Adolescent GASDERMIN B Endocrinology Diabetes and Metabolism Population Analysis models Locus (genetics) Immunoglobulin E Polymorphism Single Nucleotide Risk Assessment Young Adult Risk Factors Genotype Humans Immunology and Allergy Medicine Genetic Predisposition to Disease education Genetic Association Studies Asthma education.field_of_study Jordan biology business.industry Middle Aged medicine.disease Rhinitis Allergic Neoplasm Proteins Phenotype Case-Control Studies Immunology biology.protein Female business Biomarkers |
| Zdroj: | Endocrine, Metabolic & Immune Disorders - Drug Targets. 21:472-477 |
| ISSN: | 1871-5303 |
| DOI: | 10.2174/1871530320666200604161656 |
| Popis: | Background: Gasdermin A (GSDMA) and Gasdermin B (GSDMB) have been associated with childhood and to a lesser extent with adult asthma in many populations. In this study, we investigate whether there is an association between GSDMA (rs7212938, T/G) and GSDMB (rs7216389, T/C) at locus 17q21.2 and risk of Allergic Rhinitis among Jordanians. Also, we aimed to determine if there is an association between such polymorphisms and the IgE level. Methods: The study included 112 rhinitis patients and 111 Healthy controls. Gasdermin A (GSDMA) (rs72129The study included 112 rhinitis patients and 111 Healthy controls. Gasdermin A (GSDMA) (rs7212938, T/G) and Gasdermin B (rs7216389, T/C) polymorphisms were genotyped using the PCRRFLP method.38, T/G) and Gasdermin B (rs7216389, T/C) polymorphisms were genotyped using the PCR-RFLP method. Results: On the genotype level, three analysis models were applied namely co-dominant, dominant and recessive genotypes. GSDMB CC genotype was found to have a significant protective effect against allergic Rhinitis (< 0.05). cc genotype was also significantly associated with higher IgE level among the studied population. Conclusion: The GSDMB CC of homozygous minor genotype showed a protective effect against Allergic rhinitis. It also was found to be significantly associated with lower IgE level among the studied population. No association was found between GSDMA with the risk of allergic Rhinitis. |
| Databáze: | OpenAIRE |
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