Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
| Autor: | Elsa L. Segura, Zunilda Sánchez, Graciela Russomando, Lola Barrionuevo, Sergio Sosa-Estani, Isabel Marcela Alvarez, María Cristina Mallimaci, Carlos Lopez, Carina Sijvarger |
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| Rok vydání: | 2010 |
| Předmět: |
Chagas disease
medicine.medical_specialty CIENCIAS MÉDICAS Y DE LA SALUD Trypanosoma cruzi Argentina Ciencias de la Salud Neuraminidase Enzyme-Linked Immunosorbent Assay Biology T.cruzi INFECTION IN INFANTS IN USHUAIA ARGENTINA Serology purl.org/becyt/ford/3.3 [https] CONGENITAL T. cruzi TRANSMISSION Antigen Pregnancy Trypanosomiasis Virology parasitic diseases medicine Disease Transmission Infectious Humans Glycoproteins Salud Ocupacional Transmission (medicine) Infant Newborn Infant Articles medicine.disease biology.organism_classification Infectious Diseases Early Diagnosis Immunology Tropical medicine CHAGAS' DISEASE AMERICAN TRYPANOSOMIASIS purl.org/becyt/ford/3 [https] Parasitology Female DIAGNOSIS USING SHED ACUTE PHASE ANTIGEN |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 1476-1645 |
| Popis: | Chagas' disease, or American trypanosomiasis, is caused by the protozoan parasite Trypanasoma cruzi. It is estimated that 15,000 new cases of congenital T. cruzi transmission occur in the Americas each year. The aim of this study was to estimate the rate of congenital T. cruzi infection in infants born to infected women living in Ushuaia, Argentina, as well to assess a serologic test using Shed Acute Phase Antigen (SAPA) for a timely diagnosis of congenital infection. The rate of congenital infection among children in the study was 4.4% (3/68). Our results show that for infants younger than 30 days of age, matched blood samples from mother and infant were capable of identifying congenital transmission of infection using an enzyme-linked immunosorbent assay with SAPA. For infants older than 3 months, congenital infection could be ruled out using the same procedure Fil: Mallimaci, María Cristina. Hospital Regional Ushuaia; Argentina Fil: Sosa-Estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Russomando, Graciela Mabel. Universidad Nacional de Asunción; Paraguay Fil: Sanchez, Zunilda. Universidad Nacional de Asunción; Paraguay Fil: Sijvarger, Carina. Hospital Regional Ushuaia; Argentina Fil: Alvarez, Isabel Marcela. Hospital Regional Ushuaia; Argentina Fil: Barrionuevo, Lola. Hospital Regional Ushuaia; Argentina Fil: Lopez, Carlos. Hospital Regional Ushuaia; Argentina Fil: Segura, Elsa Leonor. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| Databáze: | OpenAIRE |
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