The Use of Telemetry Technology to Test the Proerectile Effect of Melanotan-II (MT-II) in Conscious Rats
| Autor: | Anne-Sophie Rössler, Jacques Bernabé, Pierre Clément, S. Droupy, Laurent Alexandre, François Giuliano |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Consciousness Urology medicine.medical_treatment Blood Pressure Peptides Cyclic Range finding Rats Sprague-Dawley Telemetry Animals Medicine Saline Monitoring Physiologic business.industry Experimental model Penile Erection Melanotan II Rats Surgery alpha-MSH Anesthesia business Penis medicine.drug |
| Zdroj: | European Urology. 48:145-152 |
| ISSN: | 0302-2838 |
| DOI: | 10.1016/j.eururo.2005.02.023 |
| Popis: | Objective: The aim of this study is to demonstrate that monitoring, by means of telemetry technology, the increases in intracavernosal pressure (ICP) in freely moving rats using melanotan-II (MT-II) as a proerectile inducer compound is a relevant experimental model to investigate the effects of pharmacological agents on erection. Methods: Adult rats were implanted in the corpus cavernosum with a pressure sensor which permitted telemetric monitoring of ICP in freely moving animals following MT-II (0.1, 0.3 and 1mg/kg) or saline i.v. injections. ICP was also measured after MT-II (0.1, 0.3 or 1mg/kg) or saline i.v. delivery in anesthetized rats. Results: In conscious rats, MT-II (1mg/kg) significantly increased overall erectile activity compared to saline. In anesthetized rats, MT-II-induced increase in overall erectile activity was not statistically significant but displayed a similar pattern. Conclusions: The use of telemetry technology allowed to collect quantifiable and reliable data regarding the proerectile activity of MT-II in physiological conditions. The telemetry model appears suitable for investigating the potential inducer proerectile properties of pharmacological agents. |
| Databáze: | OpenAIRE |
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