The effect of short term feeding of the antioxidant triethyleneglycol-bis-3(3-tert-butyl-4-hydroxy-5-methyl)propionate on serum thyrotropin and thyroid hormones in the male rat
| Autor: | Albert G. Burger, W. Stäubli, Cristiana E. Juge-Aubry, S. Muakkassah-Kelly, Anne-Lise Krinke, Wojciech Malinowski, F. Waechter, Philip Bentley |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Thyroid Hormones medicine.medical_specialty Time Factors Thyroid Gland Thyrotropin Toxicology Antioxidants Polyethylene Glycols Muscle hypertrophy chemistry.chemical_compound Internal medicine Follicular phase medicine Animals Pharmacology chemistry.chemical_classification Triiodothyronine Dose-Response Relationship Drug Body Weight Thyroid Hypertrophy Organ Size Reverse triiodothyronine Diet Rats Endocrinology medicine.anatomical_structure Liver chemistry Pituitary Gland Toxicity Thyroidectomy Propionate Hormone |
| Zdroj: | Toxicology and Applied Pharmacology. 107:129-140 |
| ISSN: | 0041-008X |
| Popis: | Male rats were fed triethyleneglycol-bis-3(3-tert-butyl-4-hydroxy-5-methyl)propionate (TK 12627) admixed with the food at a concentration of 1000 ppm for 3, 6, 13, and 20 days. Treatment resulted in time-dependent and marked increases in serum levels of thyrotropin (TSH) and reverse triiodothyronine (rT 3 ). Serum levels of thyroxine (T 4 ) were slightly and transiently decreased, whereas triiodothyronine (T 3 ) levels decreased by 35–50% at all time periods. Treatment with 50, 150, 500, and 1000 ppm for 2 weeks resulted in dose-related increases in thyroid and liver weights, follicular hypertrophy of the thyroid, morphological changes of the pituitaries, liver hypertrophy, and similar changes in the serum parameters described above. At 50 ppm, no alterations in the weights and morphology of the liver, thyroid, or pituitary nor in the serum levels of TSH or T 4 were observed. The effects of TK 12627 observed at a dose of 1000 ppm for 2 weeks were reversible after cessation of treatment. Decreases in T 3 , increases in rT 3 , and no change in T 4 serum levels were also obtained when thyroidectomized T 4 -substituted rats were treated with 1000 ppm TK 12627 for 28 days, indicating that the effects of TK 12627 are probably due to inhibition of the 5′ monodeiodination of T 4 to T 3 and rT 3 to diiodothyronine with compensatory increases in thyroid hormone conjugation at extrathyroidal sites. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|