Simultaneous hepatosplenic T-cell lymphoma and myelofibrosis
| Autor: | Lawrence Kass, Chung-Che Jeff Chang, Ronald P. Cleveland, Ali Gabali, Tarek Jazaerly |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Axillary Lymph Node Biopsy
Pathology medicine.medical_specialty medicine.diagnostic_test Hepatosplenic T-cell lymphoma business.industry Case Report medicine.disease liver CD3 Lymphoma Lymphatic system medicine.anatomical_structure Jak2 T-cell Biopsy medicine T-cell lymphoma Medicine Bone marrow business Myelofibrosis |
| Zdroj: | Avicenna Journal of Medicine Avicenna Journal of Medicine, Vol 04, Iss 02, Pp 34-36 (2014) |
| ISSN: | 2249-4464 2231-0770 |
| Popis: | Hepatosplenic T-cell lymphoma (HSTL) is a rare T-cell neoplasm of the lymphoid system. This type of lymphoma is characterized by sinusoidal infiltration of spleen, liver, bone marrow and lymph nodes by neoplastic lymphocytes. Here, we discuss a patient who had a left axillary lymph node biopsy with characteristic histological and immunohistochemical features of HSTL. In addition, infiltrating neoplastic T-cells and simultaneous characteristic features of myelofibrosis (MF) were also present in the bone marrow biopsy specimen. In contrast to secondary MF, primary MF is a progressive disease and may significantly affect the prognosis of coexisting HSTL. There are few reports in the literature talking about mild bone marrow fibrosis in association with T cell lymphoma, however marked increase in bone marrow fibrosis and HSTL never being reported. This case is shedding light on HSTL and marked increase in bone marrow fibrosis. |
| Databáze: | OpenAIRE |
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