Safety Profiles and Pharmacovigilance Considerations for Recently Patented Anticancer Drugs: Cutaneous Melanoma
| Autor: | Giulia Fornasier, Paolo Baldo, Maria Antonietta Pizzichetta, Debora Basile, Francesco Lo Re, C. Lisanti, Fabio Puglisi, Giuseppe Corona |
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| Přispěvatelé: | Pizzichetta, Maria A, Basile, Debora, Lisanti, Camilla, Baldo, Paolo, Fornasier, Giulia, Lo Re, Francesco, Corona, Giuseppe, Puglisi, Fabio |
| Rok vydání: | 2018 |
| Předmět: |
advanced melanoma
Cancer Research Skin Neoplasms medicine.medical_treatment Targeted therapy Pharmacovigilance 0302 clinical medicine Antineoplastic Agents Immunological Drug Discovery Pharmacology (medical) 030212 general & internal medicine Molecular Targeted Therapy Neoplasm Metastasis Drug Approval Melanoma adverse drug reactions Clinical Trials as Topic Antibodies Monoclonal General Medicine targeted therapy side effects Oncology 030220 oncology & carcinogenesis immunotherapy drug-related toxicity Proto-Oncogene Proteins B-raf medicine.medical_specialty side effect adverse drug reaction Antineoplastic Agents Patents as Topic 03 medical and health sciences medicine Humans Target therapy Intensive care medicine Protein Kinase Inhibitors Advanced melanoma business.industry Adjuvant melanoma pharmacovigilance Immunotherapy medicine.disease Cutaneous melanoma Skin cancer business |
| Zdroj: | Recent patents on anti-cancer drug discovery. 14(3) |
| ISSN: | 2212-3970 |
| Popis: | Background:Malignant melanoma is a skin cancer responsible for 90% of cutaneous cancer- related deaths. In recent years, breakthroughs in treatment strategy have revolutionized the prognosis in both early and advanced melanoma patients. In particular, treatment with monoclonal antibodies targeting co-inhibitory checkpoints or specific molecular pathways leads to a new era of promising options, by prolonging the survival time of these patients.:Moreover, unlike the chemotherapy that was used until some time ago, these new drugs have a good and more manageable toxicity profile. However, because of the recent introduction in clinical practice of the new agents, there is a learning curve among physicians regarding early recognition and management of the associated side effects.Objective:The analysis of the toxicity profiles of the different agents currently studied for the treatment of early and advanced melanoma, and the description of several relevant recent patents in this field, are the aims of this review.Methods:This is a systematically conducted review based on current clinical guidelines and on international Pharmacovigilance databases (AERS-Eudravigilance - WHO Vigibase).Results:Our systematic analysis outlines a comprehensive overview of the pharmacology, clinical application and the safety of recent anticancer drugs to treat melanoma, which can be an essential instrument for health professionals and researchers.Conclusion:The new oncological therapies against melanoma are based on increasingly specific biological and immunological targets. For this reason, the potential toxicities that are expected from patients would be less relevant than the systemic "classical" chemotherapy. However, the new therapies are not free from the risk of causing adverse reactions, some of which must be managed promptly and appropriately; moreover, the multiplicity of the metabolic pathways exposes the new target therapies to relevant potential interactions. This review can help to understand how important it is not to underestimate potential adverse drug reactions related to new targeted therapies. |
| Databáze: | OpenAIRE |
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