Curcumin-loaded Nanostructured Lipid Carriers for Ocular Drug Delivery: Design Optimization and Characterization
| Autor: | Eman A. Ashour, Akash Patil, Pranjal Taskar, Soumyajit Majumdar, Prit Lakhani |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Central composite design Sonication Dispersity Pharmaceutical Science 02 engineering and technology Permeation 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Drug delivery Curcumin Particle size 0210 nano-technology Ex vivo Biomedical engineering |
| Zdroj: | J Drug Deliv Sci Technol |
| ISSN: | 1773-2247 |
| Popis: | The current study sought to formulate, optimize, and evaluate curcumin-loaded Nanostructured Lipid Carriers (NLCs) for their in vitro and ex vivo characteristics. NLCs, prepared using hot-melt emulsification and ultrasonication techniques, were optimized using a Central Composite Design (CCD) and evaluated for their in vitro physicochemical characteristics. Their stability over a 3 month period and transcorneal permeation across excised rabbit corneas (ex vivo) were assessed for the optimized NLCs. The optimized NLC, with a particle size of 66.8 ± 2 nm, polydispersity index of 0.17±0.05, entrapment efficiency of 96 ± 1.6%, and drug loading of 3.1 ± 0.05% w/w, was chosen using CCD. The optimized NLCs showed optimum ex vivo stability at 4°C for the study period and demonstrated a significant increase in curcumin permeation (~2.5-fold) across the rabbit cornea in comparison to the control. Overall, these studies indicated the successful development of NLCs using the design of experiment approach; the formulation enhanced curcumin permeation across excised corneas and did not show any harmful side effects. |
| Databáze: | OpenAIRE |
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