Symptomatic Anti-Neutrophil Cytoplasmic Antibody-Positive Disease Complicating Subacute Bacterial Endocarditis: To Treat or Not to Treat?
| Autor: | Konstantin N. Konstantinov, Michael F. Hartshorne, Antonios H. Tzamaloukas, Alexis Harris |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Vasculitis Pathology medicine.medical_specialty Renal failure Anti-neutrophil cytoplasmic antibodies Interstitial nephritis Immunology urologic and male genital diseases Eosinophilic Immunology and Allergy Medicine Endocarditis cardiovascular diseases Anti-neutrophil cytoplasmic antibody Kidney Published: May 2012 business.industry ANCA Glomerulonephritis Pauci-immune glomerulonephritis medicine.disease medicine.anatomical_structure Infective endocarditis Subacute bacterial endocarditis business |
| Zdroj: | Case Reports in Nephrology and Urology |
| ISSN: | 1664-5510 |
| Popis: | A 54-year-old man was diagnosed with Streptococcus mutans endocarditis of the mitral valve. Serological tests disclosed the presence of multiple autoantibodies including c-ANCA, anti-PR3 and anti-MPO. While the fever subsided with antibiotics, mental status and renal function deteriorated rapidly. Kidney biopsy revealed pauci-immune glomerulonephritis and acute eosinophilic interstitial nephritis. The abnormal clinical features improved rapidly after addition of corticosteroids and cyclophosphamide to the antibiotics. Immunosuppressive agents may be required in a fraction of the patients with infective endocarditis who develop ANCA and ANCA-mediated renal disease. Histological identification of the type of renal disease is imperative for the choice of the treatment. |
| Databáze: | OpenAIRE |
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