A prospective, randomized controlled trial comparing the efficacy of recombinant follicle-stimulating hormone in three different in vitro fertilization protocols
| Autor: | Geoffrey Trew, A. Ravhon, Henrietta Lawrie, Robert Winston, Stuart Lavery, Adrian Ellenbogen |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty Randomization medicine.medical_treatment Fertilization in Vitro Biology Buserelin law.invention Body Mass Index Follicle-stimulating hormone Randomized controlled trial law Pregnancy medicine Humans Prospective Studies Prospective cohort study Gynecology In vitro fertilisation Obstetrics and Gynecology Fertility Agents Female medicine.disease Recombinant Proteins Clinical trial Reproductive Medicine Female Follicle Stimulating Hormone Luteinizing hormone |
| Zdroj: | Fertility and sterility. 73(5) |
| ISSN: | 0015-0282 |
| Popis: | Objective: To compare the following IVF protocols: a short protocol and long protocols starting on day 2 or day 21. All protocols used recombinant FSH (rFSH) for ovarian stimulation. Design: Prospective, randomized study. Setting: An assisted reproduction unit at a university center. Patient(s): Patients undergoing IVF (n = 150) were treated according to one of the three treatment protocols allocated by a random method. Intervention(s): All patients used buserelin acetate and rFSH. Patients began the long protocol on day 2 (group 1) or day 21 (group 2) of the cycle. Patients in group 3 began the short protocol on day 2 of the cycle. Main Outcome Measure(s): Ovarian response, implantation rates, and pregnancy rates (PRs). Result(s): Patients treated with the short protocol (group 3) were stimulated in a shorter time, required less rFSH, and achieved higher E 2 levels. The numbers of follicles, oocytes, and embryos were similar in all three groups. The implantation rates were similar in groups 1 and 2 (11.8% and 13.3%, respectively), and both were higher than in group 3 (4.1%). Clinical PRs per oocytes retrieved were 19.6%, 18.6%, and 8.3% in groups 1, 2, and 3, respectively. Conclusion(s): The implantation rate was significantly higher with the long protocols than with the short protocol, with a tendency for a higher PR as well. |
| Databáze: | OpenAIRE |
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