Estimation of salivary sialic acid in oral premalignancy and oral squamous cell carcinoma
| Autor: | GL Pradeep, Vishakha Chaudhari, Nilima Prakash, Aarti Mahajan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Saliva Pathology medicine.medical_specialty Population Orthodontics Biology Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine education Survival rate Tumor marker Leukoplakia education.field_of_study saliva Cancer medicine.disease Sialic acid lcsh:RK1-715 oral squamous cell carcinoma stomatognathic diseases 030104 developmental biology chemistry Dysplasia sialic acid 030220 oncology & carcinogenesis lcsh:Dentistry Periodontics Original Article Oral Surgery |
| Zdroj: | Contemporary Clinical Dentistry Contemporary Clinical Dentistry, Vol 7, Iss 4, Pp 451-456 (2016) |
| ISSN: | 0976-2361 0976-237X |
| Popis: | Aims: Oral cancer is the most life-threatening disease of oral tissues. In societies where the incidence of oral cancer is high, clinically recognizable premalignant lesions are particularly common. Diagnosing oral cancers at an early stage is critical in improving the survival rate and reducing the morbidity associated with the disease. Alterations in the sialic acid levels in cancer patients have stimulated interest in this sugar residue as a possible tumor marker. Settings and Design: The purpose of this study was to estimate the salivary sialic acid levels in patients with oral premalignancy and squamous cell carcinoma and to correlate it with their grades to develop a cost-effective and noninvasive diagnostic parameter. Materials and Methods: Unstimulated whole saliva was collected from the groups under study and subjected to biochemical analysis for determination of sialic acid levels. Statistical Analysis Used: The salivary sialic acid levels were correlated with the clinical stage and histological grade by one-way ANOVA (SPSS software version 15). Results: Salivary sialic acid was elevated in oral squamous cell carcinoma (OSCC) compared to oral premalignancy and control group. A statistically significant correlation was observed between the grades of squamous cell carcinoma, grades of dysplasia in premalignancy, and sialic acid level. Conclusion and Clinical Significance: Evaluation of salivary sialic acid levels in premalignant and malignant lesions can serve as a screening tool. The mortality and morbidity of OSCC can be reduced if the lesions are diagnosed in early precancerous states using such noninvasive diagnostic methods for screening and monitoring of the population. |
| Databáze: | OpenAIRE |
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