Exploratory case study of monozygotic twins with 22q11.2DS provides further clues to circumscribe neurocognitive markers of psychotic symptoms
| Autor: | Elodie Peyroux, Nicolas Franck, Jean-Yves Baudouin, Emilie Favre, Caroline Demily, Arnaud Leleu |
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| Přispěvatelé: | Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (CNC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Développement, Individu, Processus, Handicap, Éducation (DIPHE), Université Lumière - Lyon 2 (UL2), Institut des Sciences Cognitives (ISC), Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Baudouin, Jean-Yves, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB), Favre, Emilie |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Emotions Psychotic symptoms courbe de fréquence perception Electroencephalography 22q11.2DS 22q11.2 deletion syndrome Facial recognition system lcsh:RC346-429 [SCCO]Cognitive science 0302 clinical medicine FISH fluorescent in situ hybridization ComputingMilieux_MISCELLANEOUS media_common Cerebral Cortex medicine.diagnostic_test 05 social sciences symptôme Regular Article 22q11.2DS Penetrance phénotype Endophenotype CHG-Array complete genomic hybridization Neurology Social Perception [SCCO.PSYC] Cognitive science/Psychology [SCCO.PSYC]Cognitive science/Psychology lcsh:R858-859.7 Psychology Facial Recognition EEG electroencephalography Clinical psychology Adult Endophenotypes Cognitive Neuroscience media_common.quotation_subject psychosomatique lcsh:Computer applications to medicine. Medical informatics 050105 experimental psychology électroencéphalographie 03 medical and health sciences Facial expression perception Young Adult Psychologie (Sciences cognitives) Perception medicine DiGeorge Syndrome Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging PANSS Positive And Negative Syndrome Scale lcsh:Neurology. Diseases of the nervous system Facial expression Frequency-tagging [SCCO] Cognitive science Twins Monozygotic expression faciale Twin study FEP measurement Facial expression perception measurement Psychotic Disorders 22q11.2ds facial expression perception endophenotype psychotic symptoms frequency-tagging electroencephalography Neurology (clinical) Neurocognitive 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | NeuroImage : Clinical Neuroimage-Clinical Neuroimage-Clinical, Elsevier, 2019, 24, pp.101987. ⟨10.1016/j.nicl.2019.101987⟩ Neuroimage-Clinical, 2019, 24, pp.101987. ⟨10.1016/j.nicl.2019.101987⟩ NeuroImage: Clinical, Vol 24, Iss, Pp-(2019) NeuroImage. Clinical (24), 101987. (2019) |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2019.101987⟩ |
| Popis: | Variation in facial emotion processing abilities may contribute to variability in penetrance for psychotic symptoms in 22q11.2DS. However, the precise nature of the social cognitive dysfunction (i.e., facial expression perception vs. emotion recognition), the potential additional roles of genetic and environmental variabilities, and consequently the possibility of using this neurocognitive marker in clinical monitoring remain unclear. The present case study aimed at testing the hypothesis that when confounding factors are controlled, the presence of psychotic symptoms in 22q11.2DS is associated, at the individual level, with a neural marker of facial expression perception rather than explicit emotional face recognition. Two monozygotic twins with 22q11.2DS discordant for psychiatric manifestations performed (1) a classical facial emotion labelling task and (2) an implicit neural measurement of facial expression perception using a frequency-tagging approach in electroencephalography (EEG). Analysis of the periodic brain response elicited by a change of facial expression from neutrality indicated that the twin with psychotic symptoms did not detect emotion among neutral faces while the twin without the symptoms did. In contrast, both encountered difficulties labelling facial emotion. The results from this exploratory twin study support the idea that impaired facial expression perception rather than explicit recognition of the emotion expressed might be a neurocognitive endophenotype of psychotic symptoms that could be reliable at a clinical level. Although confirmatory studies should be required, it facilitates further discussion on the etiology of the clinical phenotype in 22q11.2DS. Highlights • Study design is a privileged opportunity to highlight reliable endophenotypes of psychiatric symptoms at an individual level • Impaired facial expression perception rather than explicit recognition might be an endophenotype of psychotic symptoms • Further discussion on the etiology of the incomplete penetrance for psychotic symptoms in 22q11.2DS |
| Databáze: | OpenAIRE |
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