Vascular Density Does Not Predict Future Metastatic Disease in Clinical Stage 1 Non-Seminomatous Germ Cell Tumours of the Testis
| Autor: | T. M. Maher, A.H.S. Lee |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Histology Time Factors Adolescent Angiogenesis Urology CD34 Disease Testicle Biology Pathology and Forensic Medicine Embryonal carcinoma Tumour tissue Testicular Neoplasms Recurrence Field size medicine Humans Stage (cooking) Neoplasm Staging Neovascularization Pathologic business.industry Teratoma Cancer General Medicine Middle Aged medicine.disease Prognosis medicine.anatomical_structure Immunohistochemistry Blood Vessels Germinoma business Orchiectomy Germ cell |
| Zdroj: | The Journal of Urology. :1025-1026 |
| ISSN: | 0022-5347 |
| DOI: | 10.1097/00005392-199903000-00085 |
| Popis: | Aim: This study aimed to determine whether patients with stage 1 testicular non seminomatous germ cell tumours (NSGCT) with high vascular density have a greater risk of disease recurrence than those with a low vascular density. Methods and results: Orchidectomy specimens from 42 patients with stage 1 NSGCT, treated by orchidectomy and surveillance alone, were studied. Vessel density was counted in tumour sections immunohistochemically stained for CD34. The mean of the three highest counts (× 250, field size 0.67 mm2) for each tumour was used. Tumour vessel density was very similar for relapsing and non relapsing patients. Vascular invasion was the only variable significantly predictive of disease recurrence at 2 years post-orchidectomy (P = 0.025). There was wide variation of vessel counts between different blocks of a tumour, compared with interobserver variation. The tumour tissue type in the area of highest vessel density was embryonal carcinoma in 50% and teratoma (mature or immature) in 38%. Conclusions: We confirmed the value of vascular invasion as a prognostic marker in stage 1 NSGCT. Tumour vessel density was of no prognostic value. Two factors may contribute to this. First, there was wide variation of vessel density between different blocks of a tumour. Second, the most vascular area in a tumour was frequently in low-grade tumour. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|