Serological, virological and histopathological study of an outbreak of sleeping disease in farmed rainbow trout Oncorhynchus mykiss
| Autor: | M F McLoughlin, H. M. Rowley, H Jewhurst, D A Graham, K. McKenzie, D. Todd, E. J. Branson |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Pathology Time Factors Population Fisheries Physiology Alphavirus Aquatic Science Antibodies Viral Serology Disease Outbreaks Fish Diseases Seroepidemiologic Studies medicine Seroprevalence Animals Longitudinal Studies Prospective Studies education Muscle Skeletal Pancreas Ecology Evolution Behavior and Systematics education.field_of_study biology Alphavirus Infections Myocardium Outbreak biology.organism_classification Oncorhynchus mykiss Oncorhynchus Histopathology Rainbow trout Viral disease |
| Zdroj: | Diseases of aquatic organisms. 74(3) |
| ISSN: | 0177-5103 |
| Popis: | A prospective longitudinal survey for sleeping disease (SD) was carried out over a 20 wkperiod on a caged freshwater population of farmed rainbow trout Oncorhynchus mkyiss . Pancreas,heart and red and white skeletal muscle were examined histologically and the presence and severityof lesions recorded. Sera were tested for viraemia with Salmonid Alphavirus (SAV) and for virus neu-tralizing (VN) antibodies. Viraemia was detected for 4 wk, beginning at Week 6 and with a peakprevalence of 57.9% at Week 7. Clinical signs and mortalities appeared at Week 8. Total mortality inthe study cage from Week 6 onward was 6.3%, but other cages at the site had mortality levels of upto 47.2%. VN antibodies were first detected at Week 9, with seroprevalence increasing to 80% by theend of the study (Week 20). Geometric mean antibody titres peaked at 1/89.4 at Week 17. Histologi-cal lesions were first detected at Week 7 (pancreas only), before increasing in prevalence and sever-ity to peak at Weeks 9 and 10. The majority of lesions were resolved by Week 15.KEY WORDS: Sleeping disease · Rainbow trout · Longitudinal survey · Antibody · Viraemia ·Histopathology |
| Databáze: | OpenAIRE |
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