Role of flavonoid troxerutin on blood pressure oxidative stress and regulation of lipid metabolism
| Autor: | Dhanasekaran Saranya, Boobalan Raja, Rajendran Prabhu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Vitamin medicine.medical_specialty Troxerutin Thiobarbituric acid Blood Pressure 030204 cardiovascular system & hematology medicine.disease_cause Antioxidants General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine TBARS Animals Rats Wistar General Immunology and Microbiology Vitamin C Lipid metabolism Glutathione Lipid Metabolism Hydroxyethylrutoside Oxidative Stress 030104 developmental biology Endocrinology chemistry Lipid Peroxidation Oxidative stress medicine.drug |
| Zdroj: | Frontiers in Bioscience. 11:121-129 |
| ISSN: | 1945-0508 1945-0494 |
| DOI: | 10.2741/e851 |
| Popis: | The objective of the present study was to investigate the effects of troxerutin (TX) on Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension in male albino Wistar rats. L-NAME (40mg/kg body weight (bw)) administration caused a sustained increase in systolic blood pressure (SBP), levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), tissue lipids (liver and kidney) such as total cholesterol (TC), triglycerides (TG), free fatty acids (FFA), and significant decrease in the activities of enzymatic antioxidants, phospholipids (PL) and levels of non enzymatic antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E. To assess the toxicity if any of TX treatment, hepatic and renal function markers were measured. TX supplementation throughout the experimental period significantly brings back all the above parameters. Among the three doses (25, 50, and 100 mg/kg) of TX, 100 mg/kg dosage exerts optimum protection against L-Name induced hypertension. These results suggest that TX has enough potential to attenuate hypertension, oxidative stress and dyslipidemia in L-NAME induced hypertensive rats. |
| Databáze: | OpenAIRE |
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