Association of P10L Polymorphism in Melanopsin Gene with Chronic Insomnia in Mexicans
| Autor: | Kricel Perez Conde-Andreu, Jaime Paul Gutiérrez-Amavizca, Jorge Alberto Pérez-León, Ernesto Prado Montes de Oca, Cesar Heriberto Ruíz-Marquez, Bianca Ethel Gutiérrez-Amavizca, Oscar David Castro, Ricardo Pérez Calderón, Marisela Aguirre Ramírez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
retina Health Toxicology and Mutagenesis insomnia chronotypes lcsh:Medicine Single-nucleotide polymorphism Pilot Projects OPN4 gene Article 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Internal medicine Sleep Initiation and Maintenance Disorders medicine Insomnia Humans business.industry Epworth Sleepiness Scale lcsh:R Public Health Environmental and Occupational Health Case-control study Rod Opsins Chronotype Odds ratio 030227 psychiatry Exact test Case-Control Studies medicine.symptom business 030217 neurology & neurosurgery melanopsin SNPs |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 18, Iss 571, p 571 (2021) International Journal of Environmental Research and Public Health Volume 18 Issue 2 |
| ISSN: | 1661-7827 1660-4601 |
| Popis: | The aim of this pilot study was to determine the association of the P10L (rs2675703) polymorphism of the OPN4 gene with chronic insomnia in uncertain etiology in a Mexican population. A case control study was performed including 98 healthy subjects and 29 individuals with chronic insomnia not related to mental disorders, medical condition, medication or substance abuse. Samples were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Genetic analyses showed that the T allele of P10L increased risk to chronic insomnia in a dominant model (p = 1 × 10&minus 4 odds ratio (OR) = 9.37, CI = 8.18&ndash 335.66, Kelsey statistical power (KSP) = 99.9%), and in a recessive model (p = 7.5 × 5, OR = 9.37, KSP = 99.3%, CI = 2.7&ndash 34.29). In the insomnia group, we did not find a correlation between genotypes and chronotype (p = 0.219 Fisher&rsquo s exact test), severity of chronic insomnia using ISI score (p = 0.082 Fisher&rsquo s exact test) and ESS score (p ˃ 0.999 Fisher&rsquo s exact test). However, evening chronotype was correlated to daytime sleepiness severity, individuals with an eveningness chronotype had more severe drowsiness according to their insomnia severity index (ISI) score (p = 0.021 Fisher&rsquo s exact test) and Epworth sleepiness scale (ESS) score (p = 0.015 Fisher&rsquo s exact test) than the morningness and intermediate chronotype. We demonstrated that the T allele of the P10L polymorphism in the OPN4 gene is associated with chronic insomnia in Mexicans. We suggest the need to conduct larger studies in different ethnic populations to test the probable association and function of P10L and other SNPs in the OPN4 gene and in the onset of chronic insomnia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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