Angiopoietin‐Tie signaling in kidney diseases: an updated review
| Autor: | Di Zhang, Chun Zhang, Liang Wu, Qing Chen, Fang-Fang He, Zhen-Qiong Li, Yi Zhao, Yu-Mei Wang, Zhao-Hua Jiang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Angiogenesis
Biophysics Kidney development Biochemistry Receptor tyrosine kinase Receptors TIE Nephropathy Diabetic nephropathy Angiopoietin 03 medical and health sciences Structural Biology Genetics Animals Humans Medicine Molecular Biology 030304 developmental biology 0303 health sciences Kidney biology business.industry 030302 biochemistry & molecular biology Angiopoietins Cell Biology medicine.disease medicine.anatomical_structure Cancer research biology.protein Kidney Diseases business Signal Transduction |
| Zdroj: | FEBS Letters. 593:2706-2715 |
| ISSN: | 1873-3468 0014-5793 |
| DOI: | 10.1002/1873-3468.13568 |
| Popis: | Angiopoietins (Angs) are a family of vascular growth factors that share multiple cellular functions related to cell survival, proliferation, and migration. Angs play physiological and pathological roles through the Tie tyrosine kinase receptors. The Ang-Tie signaling pathway participates in the developmental and tumor-induced angiogenesis and is also involved in many disease settings, such as vascular diseases, systemic inflammation, and cancers. Since Angs are widely expressed in the kidney, an enormous amount of research focuses on their roles in the kidney. In this review, we describe the biological functions of the Ang-Tie signaling pathway and summarize their roles in kidney development and maturation, acute and chronic kidney diseases, diabetic nephropathy, lupus nephropathy, hemolytic uremic syndrome, end-stage renal diseases, and renal cell carcinoma. Understanding the molecular mechanisms of Ang-Tie signaling may reveal potential therapeutic targets for preventing or alleviating kidney diseases. |
| Databáze: | OpenAIRE |
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