Feasibility and clinical integration of molecular profiling for target identification in pediatric solid tumors
Autor: | Olivier Delattre, Gaëlle Pierron, Christophe Le Tourneau, Virginie Bernard, Eve Lapouble, Ivan Bièche, Paul Fréneaux, Caroline Oudot, Estelle Thebaud, Thomas Pincez, Hélène Pacquement, Isabelle Aerts, Nathalie Clément, Gudrun Schleiermacher, Cécile Vérité, Jean Michon, Maud Kamal, Sophie Taque, Irene Jiménez, Daniel Orbach, Franck Bourdeaut, François Doz, Cormac Owens |
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Přispěvatelé: | Département d'oncologie pédiatrique [Institut Curie, Paris], Institut Curie [Paris], Service de génétique, Institut Curie Paris, Unité de génétique et biologie des cancers (U830), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Limoges, Risques cliniques et sécurité en santé des femmes et en santé périnatale (RISCQ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Département d'Oncologie Médicale [Institut Curie, Paris], Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Annenberg Foundation Fondation Nelia et Amadeo Barletta, This study was supported by the Annenberg Foundation, the Nelia and Amadeo Barletta Foundation (FNAB), the Associations Enfants et Sant?, Les Bagouz ? Manon, Les Amis de Claire, Hubert Gouin Enfance et Cancer and Meghanora. The authors declare that there is no conflict of interest. |
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Oncology Adult Male medicine.medical_specialty Poor prognosis Adolescent medicine.medical_treatment molecular profiling [SDV]Life Sciences [q-bio] Bioinformatics Targeted therapy 03 medical and health sciences Neuroblastoma 0302 clinical medicine Internal medicine medicine Tumor board Humans Solid tumor Child Comparative Genomic Hybridization business.industry Refractory Disease High-Throughput Nucleotide Sequencing Infant Mean age Sarcoma clinical trial Hematology Glioma 3. Good health Clinical trial 030104 developmental biology 030220 oncology & carcinogenesis Child Preschool array comparative genomic hybridization Pediatrics Perinatology and Child Health Female next-generation sequencing solid tumor business Comparative genomic hybridization |
Zdroj: | Pediatric Blood and Cancer Pediatric Blood and Cancer, Wiley, 2017, 64 (6), ⟨10.1002/pbc.26365⟩ |
ISSN: | 1545-5009 1545-5017 |
Popis: | International audience; Background: The role of tumor molecular profiling in directing targeted therapy utilization remains to be defined for pediatric tumors. We aimed to evaluate the feasibility of a sequencing and molecular biology tumor board (MBB) program, and its clinical impact on children with solid tumors. Procedure: We report on a single-center MBB experience of 60 pediatric patients with a poor prognosis or relapsed/refractory solid tumors screened between October 2014 and November 2015. Tumor molecular profiling was performed with panel-based next-generation sequencing and array comparative genomic hybridization. Results: Mean age was 12 ± 5.7 years (range 0.1–21.5); main tumor types were high-grade gliomas (n = 14), rare sarcomas (n = 9), and neuroblastomas (n = 8). The indication was a poor prognosis tumor at diagnosis for 16 patients and relapsed (n = 26) or refractory disease (n = 18) for the remaining 44 patients. Molecular profiling was feasible in 58 patients. Twenty-three patients (40%) had a potentially actionable finding. Patients with high-grade gliomas had the highest number of targetable alterations (57%). Six of the 23 patients subsequently received a matched targeted therapy for a period ranging from 16 days to 11 months. The main reasons for not receiving targeted therapy were poor general condition (n = 5), pursuit of conventional therapy (n = 6), or lack of pediatric trial (n = 4). Conclusions: Pediatric molecular profiling is feasible, with more than a third of patients being eligible to receive targeted therapy, yet only a small proportion were treated with these therapies. Analysis at diagnosis may be useful for children with very poor prognosis tumsors. |
Databáze: | OpenAIRE |
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