Secondary metabolites and bioactivities ofMyrtus communis
| Autor: | Amany A. Sleem, Ezzel-Din A El-Khrisy, Mahmoud I. Nassar, Elsayed A Aboutabl, Rania F. Ahmed, Khaled M. Ibrahim |
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| Rok vydání: | 2010 |
| Předmět: |
Pharmacology
Myrtus communis Volatile oil Traditional medicine biology medicine.drug_class Plant composition LD50 biology.organism_classification Median lethal dose antinociceptive Anti-inflammatory chemistry.chemical_compound chemistry Drug Discovery medicine Organic chemistry Original Article Myricetin Gallic acid Medicinal plants Antihyperglycemic anti-inflammatory Myrtus |
| Zdroj: | Pharmacognosy Research |
| ISSN: | 0974-8490 |
| DOI: | 10.4103/0974-8490.75449 |
| Popis: | Background: Myrtus species are characterized by the presence of phenolic acids, flavonoids, tannins, volatile oils and fatty acids. They are remedies for variety of ailments. This study therefore investigated medicinal effects of Myrtus communis L. Methods: Bioactivity studies of Myrtus communis L. leaves were carried out on volatile oil, 7% methanol and aqueous extracts and the isolated compounds myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝-rhamnopyranoside and gallic acid. Results: Determination of the median lethal dose (LD 50 ) revealed that the volatile oil, alcoholic and aqueous extracts were practically nontoxic and highly safe as no lethality was observed. The tested materials (volatile oil, alcoholic and aqueous extracts, myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝-rhamnopyranoside and gallic acid) showed significant antihyperglycemic, anti-inflammatory and antinociceptive effects as compared with control groups and reference drugs. Conclusion : Administration of extracts of M. communis leaves could be safe at the dose used in this study. |
| Databáze: | OpenAIRE |
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