Associations Between Eight Earth Observation-Derived Climate Variables and Enteropathogen Infection: An Independent Participant Data Meta-Analysis of Surveillance Studies With Broad Spectrum Nucleic Acid Diagnostics
| Autor: | Josh M. Colston, Benjamin F. Zaitchik, Hamada S. Badr, Eleanor Burnett, Syed Asad Ali, Ajit Rayamajhi, Syed M. Satter, Daniel Eibach, Ralf Krumkamp, Jürgen May, Roma Chilengi, Leigh M. Howard, Samba O. Sow, M. Jahangir Hossain, Debasish Saha, M. Imran Nisar, Anita K. M. Zaidi, Suman Kanungo, Inácio Mandomando, Abu S. G. Faruque, Karen L. Kotloff, Myron M. Levine, Robert F. Breiman, Richard Omore, Nicola Page, James A. Platts‐Mills, Ulla Ashorn, Yue‐Mei Fan, Prakash Sunder Shrestha, Tahmeed Ahmed, Estomih Mduma, Pablo Penatero Yori, Zulfiqar Bhutta, Pascal Bessong, Maribel P. Olortegui, Aldo A. M. Lima, Gagandeep Kang, Jean Humphrey, Andrew J. Prendergast, Robert Ntozini, Kazuhisa Okada, Warawan Wongboot, James Gaensbauer, Mario T. Melgar, Tuula Pelkonen, Cesar Mavacala Freitas, Margaret N. Kosek |
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| Přispěvatelé: | HUS Children and Adolescents, Children's Hospital, Tampere University, BioMediTech, Clinical Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
AMBIENT-TEMPERATURE
YOUNG-CHILDREN pediatrics Epidemiology Health Toxicology and Mutagenesis General or Miscellaneous TIME-SERIES Management Monitoring Policy and Law infectious diseases Environmental protection GLOBAL ENTERIC MULTICENTER RELATIVE-HUMIDITY climate hydrometeorology weather diarrheal disease TD169-171.8 DIARRHEAL DISEASE DEVELOPING-COUNTRIES ROTAVIRUS VACCINE Waste Management and Disposal Water Science and Technology Global and Planetary Change PATHOGENS 318 Medical biotechnology Public Health Environmental and Occupational Health Geohealth Pollution 3142 Public health care science environmental and occupational health SURVIVAL Impacts of Climate Change: Human Health Public Health 3111 Biomedicine Research Article |
| Zdroj: | GeoHealth, 6(1):e2021GH000452 GeoHealth GeoHealth, Vol 6, Iss 1, Pp n/a-n/a (2022) |
| Popis: | Diarrheal disease, still a major cause of childhood illness, is caused by numerous, diverse infectious microorganisms, which are differentially sensitive to environmental conditions. Enteropathogen‐specific impacts of climate remain underexplored. Results from 15 studies that diagnosed enteropathogens in 64,788 stool samples from 20,760 children in 19 countries were combined. Infection status for 10 common enteropathogens—adenovirus, astrovirus, norovirus, rotavirus, sapovirus, Campylobacter, ETEC, Shigella, Cryptosporidium and Giardia—was matched by date with hydrometeorological variables from a global Earth observation dataset—precipitation and runoff volume, humidity, soil moisture, solar radiation, air pressure, temperature, and wind speed. Models were fitted for each pathogen, accounting for lags, nonlinearity, confounders, and threshold effects. Different variables showed complex, non‐linear associations with infection risk varying in magnitude and direction depending on pathogen species. Rotavirus infection decreased markedly following increasing 7‐day average temperatures—a relative risk of 0.76 (95% confidence interval: 0.69–0.85) above 28°C—while ETEC risk increased by almost half, 1.43 (1.36–1.50), in the 20–35°C range. Risk for all pathogens was highest following soil moistures in the upper range. Humidity was associated with increases in bacterial infections and decreases in most viral infections. Several virus species' risk increased following lower‐than‐average rainfall, while rotavirus and ETEC increased with heavier runoff. Temperature, soil moisture, and humidity are particularly influential parameters across all enteropathogens, likely impacting pathogen survival outside the host. Precipitation and runoff have divergent associations with different enteric viruses. These effects may engender shifts in the relative burden of diarrhea‐causing agents as the global climate changes. Key Points Many pathogens cause diarrhea in children and are affected in different ways by weather conditions like rainfall, temperature, and humidityDiarrhea‐causing bacteria infections increase in warm, humid weather and when soil is moist, though ETEC is sensitive to rainfall extremesHigh humidity decreases prevalence of several viruses, though only rotavirus increases in cold weather and following heavy surface runoff |
| Databáze: | OpenAIRE |
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