In vitro activity of CXA-101 plus tazobactam (CXA-201) against CTX-M-14- and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae
| Autor: | Inga M. Karlsson, Christian G. Giske, Yigong Ge, Emilia Titelman |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Microbiology (medical)
Tazobactam Genotype Klebsiella pneumoniae medicine.drug_class Cephalosporin Ceftazidime Penicillanic Acid Microbial Sensitivity Tests beta-Lactamases Microbiology polycyclic compounds medicine Escherichia coli Humans Escherichia coli Infections Antibacterial agent biology Broth microdilution General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Anti-Bacterial Agents Bacterial Typing Techniques Cephalosporins Klebsiella Infections Ciprofloxacin Molecular Typing Infectious Diseases Amikacin medicine.drug |
| Zdroj: | Diagnostic microbiology and infectious disease. 70(1) |
| ISSN: | 1879-0070 |
| Popis: | CXA-101, a novel cephalosporin with good antipseudomonal activity, was evaluated against a consecutive and polyclonal collection of extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli (n = 149) and Klebsiella pneumoniae (n = 20), mainly CTX-M-15- (69%) or CTX-M-14 producing (22%). A total of 41% of the E. coli isolates belonged to the international clone O25b-ST131. Broth microdilution versus CXA-101, CXA-tazobactam 4 and 8 mg/L (CXA-201), ceftazidime-tazobactam (CAT), ceftazidime-clavulanate (CAC), piperacillin-tazobactam (TZP), amoxicillin-clavulanate (ACL), ampicillin-sulbactam (ASU), and other comparators was performed, using EUCAST methodology and breakpoints. Susceptibility to CXA-201 was 96% (tazobactam 8 mg/L, tentative breakpoint S ≤ 1 mg/L), CAT 93%, CAC 95%, ACL 24%, ASU 2%, TZP 58%, ciprofloxacin 25%, levofloxacin 30%, gentamicin 54%, tobramycin 34%, amikacin 90%, and tigecycline 98%. Ninety-four percent of the TZP-resistant and all ACL-resistant isolates were CXA-201 susceptible. CXA-201 has good in vitro activity against ESBL-producing Enterobacteriaceae and might be a future therapeutic option for infections caused by TZP- and ACL-resistant isolates. |
| Databáze: | OpenAIRE |
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