The effects of acutely administered low dose sarin on cognitive behaviour and the electroencephalogram in the common marmoset

Autor: Neil G. Muggleton, E. A. M. Scott, P. C. Pearce, Deborah Ridout, H. S. Crofts
Rok vydání: 1999
Předmět:
0301 basic medicine
medicine.medical_specialty
Sarin
Concept Formation
Central nervous system
Reversal Learning
010501 environmental sciences
Audiology
Electroencephalography
01 natural sciences
Discrimination Learning
03 medical and health sciences
chemistry.chemical_compound
Cognition
biology.animal
medicine
Animals
Telemetry
Pharmacology (medical)
0105 earth and related environmental sciences
Cholinesterase
Pharmacology
biology
medicine.diagnostic_test
Dose-Response Relationship
Drug
Cambridge Neuropsychological Test Automated Battery
Marmoset
Brain
Callithrix
Frontal Lobe
Psychiatry and Mental health
Electrophysiology
030104 developmental biology
medicine.anatomical_structure
chemistry
Pattern Recognition
Visual
Toxicity
biology.protein
Acetylcholinesterase
Conditioning
Operant
Cholinesterase Inhibitors
Psychology
Neuroscience
Zdroj: Journal of psychopharmacology (Oxford, England). 13(2)
ISSN: 0269-8811
Popis: Previous studies have suggested that administration of a clinically sign-free dose of sarin to non-human primates gives rise to subtle changes in brain electrical activity as measured by electroencephalography (EEG) several months following exposure. The functional significances of such changes are unclear. The present study monitored EEG by using implantable radiotelemetry, and also assessed the performance of complex behavioural tasks, in non-human primates for up to 15 months following exposure to a low dose of sarin. Baselines of EEG and behaviour were shown to be stable over several months in control animals. The doses of sarin administered caused erythrocyte cholinesterase inhibitions of 36.4% to 67.1%. Overall, no significant changes in EEG patterns were observed although there were increases in beta 2 amplitude which approached significance (p=0.07). No deleterious effects on performance were seen on the touchscreen mediated discrimination tasks presented from the Cambridge Neuropsychological Test Automated Battery (CANTAB). This study illustrates the validity of the approach employed and makes an important contribution to the investigation of the long-term effects of organophosphorous compounds.
Databáze: OpenAIRE
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