Rates of Psychotropic Medication Use Reported by Borderline Patients and Axis II Comparison Subjects Over 16 Years of Prospective Follow-Up
| Autor: | Garrett M. Fitzmaurice, Alayna L. Harned, D. Bradford Reich, Frances R. Frankenburg, Mary C. Zanarini |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class medicine.medical_treatment Nonbenzodiazepine Article Young Adult Borderline Personality Disorder Internal medicine medicine Humans Single-Blind Method Pharmacology (medical) Longitudinal Studies Prospective Studies Psychiatry Antipsychotic Prospective cohort study chemistry.chemical_classification Psychotropic Drugs Monoamine oxidase inhibitor Mood stabilizer Psychiatry and Mental health Mood chemistry Antidepressant Female Self Report Psychology Follow-Up Studies Tricyclic |
| Zdroj: | Journal of Clinical Psychopharmacology. 35:63-67 |
| ISSN: | 0271-0749 |
| DOI: | 10.1097/jcp.0000000000000232 |
| Popis: | The purpose of this study was to assess the classes and types of psychotropic medication reported by borderline patients and axis II comparison subjects over 16 years of prospective follow-up. Medication use was assessed at baseline using a semistructured interview of proven reliability and validity as well as its follow-up analog at eight contiguous two-year follow-up periods. A significantly higher percentage of borderline patients than axis II comparison subjects reported taking an antidepressant, an anxiolytic, an antipsychotic, and a mood stabilizer over time. They also reported more commonly taking seven of the ten more specific types of medication studied (i.e., all but tricyclic antidepressants, monoamine oxidase inhibitor antidepressants [MAOIs], and atypical antipsychotics). The rates over time of taking antipsychotics and mood stabilizers were stable, while there was a significant decline in the rates of antidepressants and anxiolytics from baseline to eight-year follow-up (but not from eight to 16-year follow-up) reported by those in both study groups. In terms of specific medications, rates of atypical antidepressants and anticonvulsants were the most stable. In contrast, nonbenzodiazepine anxiolytics declined the most steadily over time, while rates of atypical antipsychotics increased significantly over the 16 years of prospective follow-up. Taken together, the results of this study suggest that a substantial percentage of borderline patients continue to use the major classes of medication over time. They also suggest that the declining rates of use tend to stabilize less than a decade after index admission. |
| Databáze: | OpenAIRE |
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