IL-1ra administration does not improve cardiac function in patients with severe sepsis
| Autor: | Gilberto Friedman, Maire P. Shelly, Gus J. Slotman, Stanley A. Nasraway, A Tenaillon, Joseph J. Bander, Paul An Van Leeuwen, Jean Louis Vincent |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty medicine.drug_class Critical Illness Sialoglycoproteins Hemodynamics Critical Care and Intensive Care Medicine Placebo Double-Blind Method Sepsis Vasoactive Multicenter trial Humans Medicine In patient Prospective Studies Infusions Intravenous Severe sepsis business.industry Receptor antagonist Myocardial Contraction Surgery Interleukin 1 Receptor Antagonist Protein Anesthesia Blood Gas Analysis Drug Monitoring business |
| Zdroj: | Journal of Critical Care. 14:69-72 |
| ISSN: | 0883-9441 |
| Popis: | Purpose: The purpose of this study was to investigate the effects of interleukin-1 receptor antagonist (IL-1ra) on myocardial function in septic patients. Materials and Methods: A subgroup of patients from a prospective, randomized, double-blind, placebo-controlled, multicenter trial was studied from 63 academic medical centers in the United States, Canada, and Europe. A subgroup of 71 patients with severe sepsis in whom vasoactive support was little altered during the study was included. The patients were randomized to receive either placebo (n = 29) or IL-1ra at a dose of 1 mg/kg/h (n = 20) or 2 mg/kg/h (n = 22). Results: Hemodynamic measurements were taken at baseline, and 1, 2, 3, 4, 8, and 12 hours after placebo or IL-1ra administration. No significant differences in hemodynamic parameters were observed between the groups or over time during the study period. Conclusions: IL-1ra administration has no effect on cardiac function in septic patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect