Dose coverage of axillary level I-III areas during whole breast irradiation with simplified intensity modulated radiation therapy in early stage breast cancer patients
| Autor: | Xin Mei, Jin Li Ma, Jeffrey Tuan, X. Chen, Zhao Zhi Yang, X. Yu, Li Zhang, Xiao Mao Guo, Guang Yu Liu, Zhi Min Shao, Zhi Rui Zhou |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty endocrine system diseases medicine.medical_treatment Breast surgery Sentinel lymph node Breast Neoplasms Radiation Dosage breast cancer Breast cancer Whole Breast Irradiation otorhinolaryngologic diseases Breast-conserving surgery medicine Humans neoplasms Mastectomy positive sentinel lymph nodes radiotherapy axillary level Aged Neoplasm Staging Sentinel Lymph Node Biopsy business.industry Axillary Lymph Node Dissection Cancer Middle Aged medicine.disease intensity modulated radiation therapy Surgery Radiation therapy stomatognathic diseases Treatment Outcome Oncology Lymphatic Metastasis Lymph Node Excision Female Radiotherapy Adjuvant Radiotherapy Intensity-Modulated Radiology Clinical Research Paper Tomography X-Ray Computed business therapeutics |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Li Zhang 1,* , Zhao-zhi Yang 1,* , Xing-xing Chen 1,* , Jeffrey Tuan 3 , Jin-li Ma 1 , Xin Mei 1 , Xiao-li Yu 1 , Zhi-rui Zhou 1 , Zhi-min Shao 2 , Guang-yu Liu 2 and Xiao-mao Guo 1 1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China 2 Department of Breast Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China 3 Department of Radiation Oncology, National Cancer Centre Singapore, Singapore * These authors have contributed equally to this work Correspondence to: Guang-yu Liu, email: // Xiao-mao Guo, email: // Keywords : breast cancer; positive sentinel lymph nodes, radiotherapy, intensity modulated radiation therapy, axillary level Received : March 27, 2015 Accepted : May 18, 2015 Published : May 27, 2015 Abstract Purpose: This study was designed to evaluate the dose coverage of axillary areas during whole breast irradiation with simplified intensity modulated radiation therapy (s-IMRT) and field-in-field IMRT (for-IMRT) in early stage breast cancer patients. Methods: Sixty-one consecutive patients with breast-conserving surgery and sentinel lymph node biopsy were collected. Two plans were created for each patient: the s-IMRT and for-IMRT plan. Dosimetric parameters of axillary areas were compared. Results: The average of mean doses delivered to the axillary level I areas in s-IMRT and for-IMRT plan were 27.7Gy and 29.1Gy ( p = 0.011), respectively. The average of V47.5Gy, V45Gy and V40Gy (percent volume receiving≥ 47.5Gy, 45Gy and 40Gy) of the axillary level I in s-IMRT plan was significantly lower than that in for-IMRT plan ( p 19.3cm and body width >31.9cm had significantly higher mean dose in axillary level I area ( p = 0.002, 0.007, 0.001, respectively). Conclusion: Compared with for-IMRT plan, the s-IMRT plan delivered lower dose to axillary level I area. For centers using s-IMRT technique, caution should be exercised when selecting to omit axillary lymph node dissection for patients with breast conserving surgery and limited positive SLNs. |
| Databáze: | OpenAIRE |
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