Growth Hormone Does Not Prevent Catabolic Side Effects of Dexamethasone in Extremely Low Birth Weight Preterm Infants with Bronchopulmonary Dysplasia - A Pilot Study
| Autor: | Giorgio Tonini, T. Pahor, Umberto de Vonderweid, F. Colonna |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Nitrogen Endocrinology Diabetes and Metabolism Birth weight Urinary system Gestational Age Pilot Projects Dexamethasone Blood Urea Nitrogen Pulmonary function testing Endocrinology Internal medicine medicine Birth Weight Humans Infant Very Low Birth Weight Urea Growth Disorders Bronchopulmonary Dysplasia C-Peptide Human Growth Hormone business.industry Obstetrics Infant Newborn Infant Gestational age Alanine Transaminase Bilirubin medicine.disease Respiration Artificial Postnatal age Low birth weight Cholesterol Bronchopulmonary dysplasia Pediatrics Perinatology and Child Health medicine.symptom business Infant Premature medicine.drug |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 10 |
| ISSN: | 2191-0251 0334-018X |
| Popis: | Recombinant human growth hormone (rhGH) may reduce the catabolic side effects of steroid therapies on children and adults, but this has never been studied in preterm infants. We performed a pilot study on 5 extremely low birth weight preterm infants (gestational age 27 +/- 3 wks, birth weight 824 +/- 160 g) still on mechanical ventilation for bronchopulmonary dysplasia at the postnatal age of 35 +/- 9 days. All were treated for 7 days with dexamethasone (0.5 mg/kg/d i.v.) and subcutaneous rhGH at different doses: 0.1 (n = 1), 0.2 (n = 2) or 0.3 (n = 2) IU/kg/day. Nutrition was kept stable. After 7 days all subjects improved their respiratory condition but body weight remained the same and urinary urea nitrogen and C-peptide were significantly higher (p < 0.001). rhGH intake strongly related to urinary excretion of urea nitrogen (r = 0.78) and C-peptide (r = 0.88). Dexamethasone improves the pulmonary function of very preterm infants with bronchopulmonary dysplasia but induces growth arrest and catabolism which are not prevented, and may be worsened, by rhGH. |
| Databáze: | OpenAIRE |
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