Plasma and erythrocyte phospholipid fatty acids composition in serbian hemodialyzed patients
| Autor: | Blazencić-Mladenović, Rasić Z, Ristić-Medié D, Perunicić G, Ristić, Aleksandra Arsic, Tepsić, Marija Poštić, Ristić G |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Erythrocytes Phospholipid Yugoslavia Critical Care and Intensive Care Medicine fatty acids lipids chemistry.chemical_compound Renal Dialysis Internal medicine Phosphatidylcholine Blood plasma medicine Humans Phospholipids phospholipids plasma Phosphatidylethanolamine chemistry.chemical_classification hemodialysis business.industry Fatty Acids General Medicine Metabolism Middle Aged medicine.disease Red blood cell medicine.anatomical_structure Endocrinology chemistry Nephrology Kidney Failure Chronic Female lipids (amino acids peptides and proteins) erythrocyte business Dyslipidemia Polyunsaturated fatty acid |
| Zdroj: | Renal Failure |
| Popis: | Dyslipidemia is one of the possible risk factors for advanced atherosclerosis in patients with chronic renal failure. Abnormal phospholipid metabolism may play an important role in the progression of atherosclerosis in patients with renal failure. The aim of this study was to determine specific characteristics of plasma and erythrocyte phospholipid content and fatty acid composition in 37 patients with chronic renal failure on hemodialysis (HD). The results were compared with the characteristics of healthy subjects. Briefly, plasma triglyceride (p lt 0.001), total cholesterol (p lt 0.05), and total phospholipids (p lt 0.01) levels were significantly higher and HDL-cholesterol level significantly lower (p lt 0.01) in HD patients. Plasma phosphatidylcholine and phosphatidylethanolamine concentration were significantly higher (p lt 0.001) in HD patients. The plasma phospholipid fatty acids composition indicated significantly (p lt 0.01) higher level of oleic (18:1 n-9) and lower levels of eicopentaenoic (20:5 n-3 EPA) and docosahexaenoic (22:6 n-3 DHA) acids (p lt 0.05). However, in HD patients, the relative concentration of plasma phospholipid n-6 polyunsaturated fatty acid (PUFA) was significantly lower (p lt 0.05). The fatty acid composition of erythrocyte phospholipid in HD patients was modified with EPA and DHA levels significantly lowered (p lt 0.05). Our results demonstrate an abnormal phospholipid metabolism and deficiency of n-3 PUFA in plasma and erythrocyte phospholipids in hemodialyzed patients. |
| Databáze: | OpenAIRE |
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