Effect of high-fat and low-fiber meals on the cell proliferation activity of colorectal mucosa
| Autor: | W. R. Bruce, Roger C. Gregoire, J. Stadler, Hanoch Kashtan, Hartley Stern, G.A. Neil, Ka Sing Yeung |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Dietary Fiber Male Cancer Research medicine.medical_specialty Time Factors Colon Medicine (miscellaneous) Rectum Biology Bile Acids and Salts chemistry.chemical_compound Feces Random Allocation Internal medicine Healthy volunteers medicine High fat Humans Fiber Intestinal Mucosa Dietary fat Analysis of Variance Nutrition and Dietetics Cell growth Hydrogen-Ion Concentration Middle Aged Dietary Fats Endocrinology medicine.anatomical_structure Oncology chemistry Dietary fiber Female Thymidine Cell Division |
| Zdroj: | Nutrition and cancer. 15(1) |
| ISSN: | 0163-5581 |
| Popis: | Normal healthy volunteers (n = 43) were divided into four groups that received diets providing low or high levels of dietary fat (33 or 96 g/day) and low or high levels of dietary fiber (6 and 41 g/day) for a period of five days. Proliferation was assessed with tritiated thymidine labeling of three rectal biopsies. After five days on the prescribed diets, the average thymidine labeling index (LI) of the group on the high fat‐low fiber diet was only 25% higher than the average LI of the group on the low fat‐high fiber diet, a difference that is not statistically significant. We conclude that a short‐term increase in dietary fat and decrease in dietary fiber does not result in a large increase in cell proliferation rate. |
| Databáze: | OpenAIRE |
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