Assessment of serum chemerin, vaspin and omentin-1 levels in patients with polycystic ovary syndrome

Autor: Yesim Guvenc, Naci Kemal Kuscu, Ahmet Var, Asli Goker
Rok vydání: 2016
Předmět:
Adult
medicine.medical_specialty
endocrine system diseases
GPI-Linked Proteins
Adipokine
030209 endocrinology & metabolism
Overweight
Biochemistry
03 medical and health sciences
0302 clinical medicine
Lectins
Internal medicine
medicine
Humans
Chemerin
In patient
adipokines
Polycystic ovary syndrome
Serpins
030219 obstetrics & reproductive medicine
biology
business.industry
Biochemistry (medical)
Case-control study
nutritional and metabolic diseases
Research Reports
Cell Biology
General Medicine
Polycystic ovary
female genital diseases and pregnancy complications
Endocrinology
omentin-1
Normal weight
Case-Control Studies
vaspin
Multivariate Analysis
biology.protein
Cytokines
Intercellular Signaling Peptides and Proteins
Regression Analysis
Female
Chemokines
medicine.symptom
business
chemerin
Zdroj: The Journal of International Medical Research
ISSN: 1473-2300
0300-0605
Popis: Objective To determine serum chemerin, vaspin and omentin-1 in overweight and normal weight patients with polycystic ovary syndrome (PCOS) and investigate the possible relationship between these adipokines and metabolic syndrome. Methods This cross sectional study enrolled women with PCOS and healthy women. Serum chemerin, vaspin and omentin-1 were assessed by enzyme-linked immunosorbent assay methods. Results Forty patients with PCOS and 30 healthy controls were included in the study. In the PCOS group, 18 women were overweight (body mass index [BMI] = 25.0–29.9 kg/m2) and 22 had normal weight (BMI = 18.5–24.9 kg/m2). Chemerin, total cholesterol, dehydroepiandrosterone sulphate and free androgen index (FAI) were significantly higher; and high-density lipoprotein cholesterol and sex hormone binding globulin were significantly lower in overweight PCOS patients compared with normal weight PCOS patients. A positive correlation was found between chemerin and BMI, triglyceride, insulin, homeostatic model assessment of insulin resistance and FAI in the PCOS group. There was no difference in serum chemerin, vaspin and omentin-1 between PCOS patients and healthy controls. Conclusion Circulating chemerin was increased in overweight compared with normal weight PCOS patients. The most predictive variables for circulating chemerin in PCOS patients were BMI, FAI and age.
Databáze: OpenAIRE
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