CRP, but not TNF-α or IL-6, decreases after weight loss in patients with morbid obesity exposed to intensive weight reduction and balneological treatment

Autor: Danuta Rość, Robert Szafkowski, Joanna Boinska, Przemysław Adamczyk, Katarzyna Stankowska, Irena Ponikowska, Barbara Góralczyk, Barbara Ruszkowska-Ciastek
Rok vydání: 2015
Předmět:
Blood Glucose
Male
Adipose tissue
Body Mass Index
chemistry.chemical_compound
High-density lipoprotein
Weight loss
Adipocyte
Adipocytes
Homeostasis
General Pharmacology
Toxicology and Pharmaceutics
medicine.diagnostic_test
biology
Articles
General Medicine
Middle Aged
Obesity
Morbid
C-Reactive Protein
Female
medicine.symptom
Adult
medicine.medical_specialty
Diet
Reducing
General Biochemistry
Genetics and Molecular Biology
Young Adult
Insulin resistance
Internal medicine
Weight Loss
medicine
Humans
Triglycerides
Aged
Caloric Restriction
Inflammation
General Veterinary
Balneology
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
Cholesterol
HDL
C-reactive protein
medicine.disease
Endocrinology
chemistry
Case-Control Studies
biology.protein
Insulin Resistance
Lipid profile
business
Body mass index
Zdroj: Journal of Zhejiang University-SCIENCE B. 16:404-411
ISSN: 1862-1783
1673-1581
DOI: 10.1631/jzus.b1400219
Popis: Objective: The aim of this study was to evaluate the concentrations of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and the degree of homeostasis model assessment-insulin resistance (HOMA-IR) in patients with morbid obesity exposed to a three-week low-calorie diet and balneotherapy. Methods: The study included 33 patients (25 females and 8 males; mean age 46 years) with body mass index (BMI) values of >40 kg/m2. Evaluations of CRP, IL-6, TNF-α, lipid profile, HOMA-IR, and fasting glucose were carried out before (baseline data) and three weeks after the treatment. The control group consisted of 20 healthy volunteers (15 females and 5 males) with a mean age of 39 years and BMI values of ≤24.9 kg/m2. Results: In the blood of patients with morbid obesity we found significantly elevated levels of CRP, TNF-α, triglycerides, HOMA-IR and fasting glucose, but a decreased level of high density lipoprotein (HDL)-cholesterol, compared with the healthy individuals. The treatment resulted in about a 9.4% reduction in body weight from 122.5 to 111.0 kg and a significant decrease in the concentration of CRP, but no change in TNF-α or IL-6. HOMA-IR was significantly reduced. Conclusions: The decrease in CRP level without changes in TNF-α or IL-6 concentrations after the low-calorie diet and balneological treatment, suggests that an essential amount of adipose tissue must be removed before proper adipocyte function is restored. The decrease in HOMA-IR indicates an improvement in insulin sensitivity, which is beneficial in obese patients.
Databáze: OpenAIRE
Externí odkaz: