Mean cell spacing abnormalities in the neocortex of patients with schizophrenia
Autor: | Christoph Schmitz, Norbert Ulfig, Hubert Korr, Harry W.M. Steinbusch, Manuel F. Casanova, Andrew E. Switala, Pawel Kreczmanski, Leonie de Zeeuw, Helmut Heinsen |
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Rok vydání: | 2004 |
Předmět: |
Adult
Male Psychosis Cell Population Cell Count Neocortex Severity of Illness Index medicine Neuropil Confidence Intervals Image Processing Computer-Assisted Humans education Biological Psychiatry Aged Neurons education.field_of_study Anatomy Middle Aged medicine.disease Psychiatry and Mental health medicine.anatomical_structure Cerebral cortex Schizophrenia Intercellular space Schizophrenic Psychology Psychology Extracellular Space Neuroscience Algorithms |
Zdroj: | Psychiatry research. 133(1) |
ISSN: | 0165-1781 |
Popis: | It has been postulated that the prefrontal cortices of schizophrenic patients have significant alterations in their interneuronal (neuropil) space. The present study re-examines this finding based on measurements of mean cell spacing within the cell minicolumn. The population studied consisted of 13 male schizophrenic patients (DSM-IV criteria) and 13 age-matched controls. Photomicrographs of Brodmann's areas 9, 4 (M1), 3b (S1), and 17 (V1) were analyzed with computerized image analysis to measure parameters of minicolumnar morphometry, i.e., columnarity index (CI), minicolumnar width (CW), dispersion of minicolumnar width ( V CW ), and mean interneuronal distance (MCS). The results indicate alterations in the mean cell spacing of schizophrenic patients according to both the lamina and cortical area examined. The lack of variation in the columnarity index argues in favor of a defect postdating the formation of the cell minicolumn. |
Databáze: | OpenAIRE |
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