DIMETHOTHIAZINE IN SPASTICITYA Further Attempt at Pharmacological Control
| Autor: | G. S. Wakefield, W. B. Matthews, G. Rushworth |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Adult
Drug Oral treatment media_common.quotation_subject Administration Oral Phenothiazines Humans Medicine Spasticity Gait Muscle Cramp media_common Phenothiazine derivative Adult patients Electromyography business.industry General Medicine Muscle Rigidity Neurology Muscle Tonus Anesthesia Injections Intravenous Neurology (clinical) Dimethothiazine medicine.symptom Decerebrate Rigidity business |
| Zdroj: | Acta Neurologica Scandinavica. 48:635-644 |
| ISSN: | 1600-0404 0001-6314 |
| DOI: | 10.1111/j.1600-0404.1972.tb07580.x |
| Popis: | Dimethothiazine was selected from laboratory data as a drug with a high activity against decerebrate rigidity and little soporific action. Its use in the treatment of spasticity was examined. By intravenous injection spasticity could be greatly reduced or abolished and relatively high oral doses produced reduction in extensor tone in the lower limbs. An uncontrolled trial of oral treatment was conducted in 42 adult patients with spasticity arising from cerebral or spinal lesions. Spasticity was reduced in 30 and markedly reduced in 15 of the 30 patients. In 20 patients some functional benefit was apparent. The use of the drug was, however, limited by the effects of prolonged high-dosage medication with a phenothiazine derivative and by the release of flexor spasm. |
| Databáze: | OpenAIRE |
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