EEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel

Autor: Atticus Hainsworth, Xianghong Arakaki, Milica G. Kramberger, Aina Puce, Giovanni B. Frisoni, Maria C. Carrillo, Doh Kwan Kim, Claudio Del Percio, Gary F. Egan, Rebecca M. Edelmayer, Jaeseung Jeong, Görsev Yener, Vesna Jelic, Bahar Güntekin, Raffaele Ferri, Pedro A. Valdes-Sosa, Giuseppe Noce, Petra Ritter, Federico Tucci, Andrea Soricelli, Flavio Nobili, Mitchell Valdés-Sosa, Stefan J. Teipel, Roberta Lizio, Claudio Babiloni, Sanjeev Kumar, Harald Hampel, Alan C. Evans, Laura Bonanni, Andrea Vergallo, Fanny M. Elahh, Perminder S. Sachdev, Ana Buján, Dirk J.A. Smit
Rok vydání: 2020
Předmět:
0301 basic medicine
Cerebrovascular disease (CVD)
Aging
physiopathology [Cognitive Dysfunction]
physiopathology [Brain]
Audiology
Electroencephalography
methods [Electroencephalography]
etiology [Cognitive Dysfunction]
physiopathology [Dementia
Vascular]
Resting state electroencephalographic (rsEEG) rhythms
0302 clinical medicine
Vascular cognitive impairment (VCI)
physiology [Evoked Potentials]
Medicine
Vascular contribution to cognitive impairment and dementia (VCID)
Evoked Potentials
media_common
medicine.diagnostic_test
General Neuroscience
Brain
Small vessel disease
Wakefulness
Vigilance (psychology)
medicine.medical_specialty
Event-related oscillations (EROs)
media_common.quotation_subject
Rest
Event-related potentials (ERPs)
Affect (psychology)
Arousal
03 medical and health sciences
Subcortical ischemic vascular disease
Dementia
Humans
Cognitive Dysfunction
ddc:610
diagnosis [Dementia
Vascular]
Vascular dementia (VaD)
Resting state fMRI
business.industry
Dementia
Vascular
etiology [Dementia
Vascular]
Neurophysiology
medicine.disease
030104 developmental biology
diagnosis [Cognitive Dysfunction]
physiology [Rest]
Neurology (clinical)
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Developmental Biology
Zdroj: Neurobiology of aging 103, 78-97 (2021). doi:10.1016/j.neurobiolaging.2021.03.003
ISSN: 1558-1497
0197-4580
DOI: 10.1016/j.neurobiolaging.2021.03.003
Popis: Vascular contribution to cognitive impairment (VCI) and dementia is related to etiologies that may affect the neurophysiological mechanisms regulating brain arousal and generating electroencephalographic (EEG) activity. A multidisciplinary expert panel reviewed the clinical literature and reached consensus about the EEG measures consistently found as abnormal in VCI patients with dementia. As compared to cognitively unimpaired individuals, those VCI patients showed (1) smaller amplitude of resting state alpha (8-12 Hz) rhythms dominant in posterior regions; (2) widespread increases in amplitude of delta (< 4 Hz) and theta (4-8 Hz) rhythms; and (3) delayed N20 0/P30 0 peak latencies in averaged event-related potentials, especially during the detection of auditory rare target stimuli requiring participants' responses in "oddball" paradigms. The expert panel formulated the following recommendations: (1) the above EEG measures are not specific for VCI and should not be used for its diagnosis; (2) they may be considered as "neural synchronization" biomarkers to enlighten the relationships between features of the VCI-related cerebrovascular lesions and abnormalities in neurophysiological brain mechanisms; and (3) they may be tested in future clinical trials as prognostic biomarkers and endpoints of interventions aimed at normalizing background brain excitability and vigilance in wakefulness.
Databáze: OpenAIRE
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