Ensheathing cells utilize dynamic tiling of neuronal somas in development and injury as early as neuronal differentiation
| Autor: | Lauren A. Green, Evan L. Nichols, Cody J. Smith |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Nervous system Neuronal soma Embryo Nonmammalian Indoles Population Cell Green Fluorescent Proteins Nerve Tissue Proteins Neural niche Biology Development lcsh:RC346-429 Animals Genetically Modified 03 medical and health sciences Developmental Neuroscience Peripheral Nerve Injuries Ganglia Spinal medicine Basic Helix-Loop-Helix Transcription Factors Animals education Zebrafish lcsh:Neurology. Diseases of the nervous system Progenitor Neurons Ensheathment education.field_of_study Sulfonamides Microscopy Confocal SOXE Transcription Factors Cell Differentiation Forkhead Transcription Factors Zebrafish Proteins biology.organism_classification Nerve Regeneration 030104 developmental biology medicine.anatomical_structure nervous system Neuron Tiling Neuroscience Developmental biology Neuroglia Research Article |
| Zdroj: | Neural Development, Vol 13, Iss 1, Pp 1-22 (2018) Neural Development |
| ISSN: | 1749-8104 |
| DOI: | 10.1186/s13064-018-0115-8 |
| Popis: | Background Glial cell ensheathment of specific components of neuronal circuits is essential for nervous system function. Although ensheathment of axonal segments of differentiated neurons has been investigated, ensheathment of neuronal cell somas, especially during early development when neurons are extending processes and progenitor populations are expanding, is still largely unknown. Methods To address this, we used time-lapse imaging in zebrafish during the initial formation of the dorsal root ganglia (DRG). Results Our results show that DRG neurons are ensheathed throughout their entire lifespan by a progenitor population. These ensheathing cells dynamically remodel during development to ensure axons can extend away from the neuronal cell soma into the CNS and out to the skin. As a population, ensheathing cells tile each DRG neuron to ensure neurons are tightly encased. In development and in experimental cell ablation paradigms, the oval shape of DRG neurons dynamically changes during partial unensheathment. During longer extended unensheathment neuronal soma shifting is observed. We further show the intimate relationship of these ensheathing cells with the neurons leads to immediate and choreographed responses to distal axonal damage to the neuron. Conclusion We propose that the ensheathing cells dynamically contribute to the shape and position of neurons in the DRG by their remodeling activity during development and are primed to dynamically respond to injury of the neuron. |
| Databáze: | OpenAIRE |
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