Doxazosin attenuates renal matrix remodeling mediated by anti-α1-adrenergic receptor antibody in a rat model of diabetes mellitus
| Autor: | De‑Zhong Li, Yan‑Yan Lin, Xue‑Ying Tan, Wei‑Wei Bai, Lin‑Shuang Zhao, Ye Liu, Chun‑Yan Xu, Jin‑Ling Xu, Yi Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty doxazosin 030204 cardiovascular system & hematology Diabetic nephropathy Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immunology and Microbiology (miscellaneous) Diabetes mellitus Internal medicine medicine Doxazosin Receptor renal matrix remodeling Kidney Creatinine business.industry Autoantibody General Medicine Articles medicine.disease α1 adrenergic receptor 030104 developmental biology Endocrinology medicine.anatomical_structure chemistry diabetes mellitus business autoantibody medicine.drug |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | Diabetic nephropathy is a major complication of diabetes mellitus (DM). Recent studies suggest that immunological mechanisms have a key role in the pathogenesis of DM, therefore these mechanisms may be important targets for diabetes therapy. The present study evaluated the effects of anti-α1-adrenergic receptor antibody (α1-R Ab) mediation and doxazosin treatment in a rat model of DM. It was observed that levels of 24-h urinary protein, serum creatinine and transforming growth factor-β1 in DM were significantly increased after α1-R Ab mediation (all P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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