Immunomodulatory Effects Mediated by Dopamine
| Autor: | Dora Luz de la Cruz-Aguilera, Rodrigo Arreola, Enrique Becerril-Villanueva, María Eugenia Garcés-Alvarez, Gabriela Hurtado-Alvarado, Lenin Pavón, Saray Quintero-Fabián, Carlos S. Cruz-Fuentes, Gilberto Pérez-Sánchez, Samantha Alvarez-Herrera, Enrique Octavio Flores-Gutierrez, Emilio Medina-Rivero |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Central Nervous System
0301 basic medicine lcsh:Immunologic diseases. Allergy Dopamine Immunology Review Article Biology Autoimmune Diseases Receptors Dopamine Reuptake Immunomodulation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dopamine receptor D2 Peripheral Nervous System Leukocytes medicine Animals Humans Immunology and Allergy Neurotransmitter Receptor Dopamine Plasma Membrane Transport Proteins Mental Disorders Dopaminergic Neurodegenerative Diseases Chemotaxis General Medicine Cell biology 030104 developmental biology Gene Expression Regulation chemistry Organ Specificity Signal transduction lcsh:RC581-607 Metabolic Networks and Pathways 030217 neurology & neurosurgery Signal Transduction medicine.drug |
| Zdroj: | Journal of Immunology Research, Vol 2016 (2016) Journal of Immunology Research |
| ISSN: | 2314-7156 2314-8861 |
| Popis: | Dopamine (DA), a neurotransmitter in the central nervous system (CNS), has modulatory functions at the systemic level. The peripheral and central nervous systems have independent dopaminergic system (DAS) that share mechanisms and molecular machinery. In the past century, experimental evidence has accumulated on the proteins knowledge that is involved in the synthesis, reuptake, and transportation of DA in leukocytes and the differential expression of the D1-like(D1R and D5R) and D2-likereceptors (D2R, D3R, and D4R). The expression of these components depends on the state of cellular activation and the concentration and time of exposure to DA. Receptors that are expressed in leukocytes are linked to signaling pathways that are mediated by changes in cAMP concentration, which in turn triggers changes in phenotype and cellular function. According to the leukocyte lineage, the effects of DA are associated with such processes as respiratory burst, cytokine and antibody secretion, chemotaxis, apoptosis, and cytotoxicity. In clinical conditions such as schizophrenia, Parkinson disease, Tourette syndrome, and multiple sclerosis (MS), there are evident alterations during immune responses in leukocytes, in which changes in DA receptor density have been observed. Several groups have proposed that these findings are useful in establishing clinical status and clinical markers. |
| Databáze: | OpenAIRE |
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