Acebutolol metabolite plasma concentration during chronic oral therapy
| Autor: | W B Ricks, DC Harrison, RA Winkle, P J Meffin |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Pharmacology
Drug Time Factors Chemistry media_common.quotation_subject Metabolite Administration Oral Arrhythmias Cardiac Acebutolol chemistry.chemical_compound Diacetolol Pharmacokinetics Plasma concentration medicine Humans Pharmacology (medical) In patient Oral therapy Research Article medicine.drug media_common |
| Zdroj: | British Journal of Clinical Pharmacology. 4:519-522 |
| ISSN: | 0306-5251 |
| DOI: | 10.1111/j.1365-2125.1977.tb00779.x |
| Popis: | 1 We have measured the plasma concentration of acebutolol and a major metabolite in patients on chronic oral therapy with this drug, using a new assay, specific for each species. Our study suggests: 2 The acetyl metabolite was present in concentrations greater than those of acebutolol at all times during the dosing interval in all seven subjects. 3 The ratio of the mean steady-state plasma concentrations of the acetyl metabolite to unchanged acebutolol was 2.7 +/- 1.0. 4 Previous studies using non-specific methods that measure plasma concentrations of the acetyl metabolite and acebutolol as a single species cannot be used to determine pharmacokinetic parameters or to provide reliable correlations of plasma drug concentration with effect. 5 Future studies determining plasma concentration of acebutolol should take this metabolite into account. 6 Further work will be necessary to determine the metabolite's contribution to acebutolol's effects in man. |
| Databáze: | OpenAIRE |
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