Angiotensin-converting enzyme insertion/deletion gene polymorphism in Egyptian children with systemic lupus erythematosus: a possible relation to proliferative nephritis
| Autor: | A Shouma, Wafaa Laimon, R Ghanem, Dina Abdel-Hady, Ayman Hammad, E M Hammad, Sohier Yahia, Sahar Hamed, Sherif R. El-Bassiony, Reham M. El-farahaty, N M Shalaby |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Genotype Lupus nephritis 030204 cardiovascular system & hematology Peptidyl-Dipeptidase A Gastroenterology Polymerase Chain Reaction Pathogenesis 03 medical and health sciences 0302 clinical medicine Rheumatology Gene Frequency immune system diseases Polymorphism (computer science) Risk Factors Internal medicine medicine Humans Lupus Erythematosus Systemic Genetic Predisposition to Disease Allele skin and connective tissue diseases Child 030203 arthritis & rheumatology Polymorphism Genetic biology business.industry Angiotensin-converting enzyme medicine.disease Angiotensin II Lupus Nephritis Mutagenesis Insertional Cross-Sectional Studies Case-Control Studies Child Preschool biology.protein Egypt Female Gene polymorphism business Gene Deletion |
| Zdroj: | Lupus. 26(7) |
| ISSN: | 1477-0962 |
| Popis: | Introduction Angiotensin-converting enzyme (ACE) is crucial in the pathogenesis of systemic lupus erythematosus through angiotensin II which regulates vascular tone and endothelial functions. Objectives To study the frequency of ACE insertion/deletion (I/D) gene polymorphism in Egyptian children with systemic lupus erythematosus and its possible relation to the renal pathology in cases with lupus nephritis. Subjects and methods The frequency of ACE gene insertion/deletion polymorphism genotypes was determined in 78 Egyptian children with systemic lupus erythematosus and compared to a matched group of 140 healthy controls using polymerase chain reaction. Results The DD genotype of the ACE gene was higher in systemic lupus erythematosus patients when compared to controls ( PConclusion The D allele and DD genotype of the ACE gene appear to be a risk factor for the susceptibility of systemic lupus erythematosus and occurrence of proliferative nephritis in Egyptian children. |
| Databáze: | OpenAIRE |
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