Evidence for the incorporation of temporal duration information in human hippocampal long-term memory sequence representations
| Autor: | Jonathan Tay, Adrian Nestor, Andy C. H. Lee, Edward B. O'Neil, Sathesan Thavabalasingam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Memory Long-Term Memory Episodic Hippocampal formation Neuropsychological Tests computer.software_genre Hippocampus 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Voxel medicine Humans 0501 psychology and cognitive sciences Episodic memory CA1 Region Hippocampal Recognition memory Brain Mapping Multidisciplinary medicine.diagnostic_test Recall Long-term memory 05 social sciences Image content Recognition Psychology Middle Aged Magnetic Resonance Imaging Temporal Lobe PNAS Plus Pattern Recognition Visual Mental Recall Time Perception Female Functional magnetic resonance imaging Psychology Neuroscience computer 030217 neurology & neurosurgery |
| Popis: | There has been much interest in how the hippocampus codes time in support of episodic memory. Notably, while rodent hippocampal neurons, including populations in subfield CA1, have been shown to represent the passage of time in the order of seconds between events, there is limited support for a similar mechanism in humans. Specifically, there is no clear evidence that human hippocampal activity during long-term memory processing is sensitive to temporal duration information that spans seconds. To address this gap, we asked participants to first learn short event sequences that varied in image content and interval durations. During fMRI, participants then completed a recognition memory task, as well as a recall phase in which they were required to mentally replay each sequence in as much detail as possible. We found that individual sequences could be classified using activity patterns in the anterior hippocampus during recognition memory. Critically, successful classification was dependent on the conjunction of event content and temporal structure information (with unsuccessful classification of image content or interval duration alone), and further analyses suggested that the most informative voxels resided in the anterior CA1. Additionally, a classifier trained on anterior CA1 recognition data could successfully identify individual sequences from the mental replay data, suggesting that similar activity patterns supported participants' recognition and recall memory. Our findings complement recent rodent hippocampal research, and provide evidence that long-term sequence memory representations in the human hippocampus can reflect duration information in the order of seconds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|