Circulating miR ‐155, let‐7c, miR ‐21, and PTEN levels in differential diagnosis and prognosis of idiopathic granulomatous mastitis and breast cancer
| Autor: | Ilhan Yaylim, Remise Gelisgen, Uğurcan Sayılı, Berrin Papila Kundaktepe, Mehmet Velidedeoglu, Hulya Aksan, Gonul Simsek, Selçuk Köksal, Hafize Uzun |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Clinical Biochemistry Breast Neoplasms Granulomatous mastitis Biochemistry Gastroenterology Diagnosis Differential miR-155 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine microRNA Biomarkers Tumor Humans Medicine PTEN Granulomatous Mastitis Noninvasive biomarkers biology business.industry PTEN Phosphohydrolase General Medicine Middle Aged Prognosis medicine.disease Fold change MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis biology.protein Molecular Medicine Female Differential diagnosis business |
| Zdroj: | BioFactors. 46:955-962 |
| ISSN: | 1872-8081 0951-6433 |
| Popis: | This study investigates whether the circulating miR-155, let-7c, miR-21, and PTEN levels to be used in the differential diagnosis of patients with idiopathic granulomatous mastitis (IGM) and breast cancer (BC). Forty-five patients with BC, 50 patients with IGM, and 48 healthy volunteers were included in the study. Serum miR-21 expression was significantly higher in BC (fold change = 2.42) and IGM group (fold change = 1.33) compared to control (p < .001). Serum miR-155 and let-7c expression levels were significantly lower in both groups compared to the control group (p < .001). miR-21 expression in BC was significantly higher than IGM (fold change = 1.976; p < .001). PTEN levels in BC were significantly higher than IGM (p < .001) and significantly lower than the control group (p < .001); the IGM group was significantly lower than the control group (p < .001). In addition to radiological data, serum miR-21 and PTEN levels may be noninvasive biomarkers that can help differentiate IGM from BC. The results of the study will lead to future studies in the differential diagnosis of IGM and BC. |
| Databáze: | OpenAIRE |
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