Captopril test in children with reflux nephropathy
| Autor: | Graham Ellis, M. Levy, Radi M A Hamed, G. A. McLorie, J. W. Balfe |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Captopril Adolescent Urology Diastole Blood Pressure Plasma renin activity Nephropathy Renin-Angiotensin System Internal medicine Renin medicine Humans Child Vesico-Ureteral Reflux Reflux nephropathy biology business.industry Angiotensin-converting enzyme medicine.disease Hypertension Renovascular Endocrinology Blood pressure Nephrology Child Preschool Creatinine Pediatrics Perinatology and Child Health biology.protein Female Kidney Diseases business hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology medicine.drug |
| Zdroj: | Pediatric Nephrology. 6:33-37 |
| ISSN: | 1432-198X 0931-041X |
| DOI: | 10.1007/bf00856826 |
| Popis: | We studied the plasma renin activity (PRA) and blood pressure (BP) responses to a single oral dose of captopril in children with renal scarring due to vesicoureteral reflux. The test was performed on 19 children, of whom 13 were normotensive and 6 hypertensive. Basal PRA was within the normal range for age for all except 1 patient. Mean basal PRA values for normotensive and hypertensive patients were not significantly different. At 90 min post captopril, the mean PRA increase was 3.61 ng/l per second (SD = 7.07) in the normotensive group but only 0.77 ng/l per second (SD = 0.83) in the hypertensive group. In 11 patients the average systolic BP 60-90 min post captopril was 0.9%-12.4% lower than the basal value. Diastolic BP decreased after captopril administration in 10 patients and increased in 9. The changes in mean arterial pressure and PRA between 0 and 90 min post captopril were inversely correlated (r = 0.605, P less than 0.01). Because of the PRA responsiveness in the normotensive patients with renal scarring, we suggest that there was activation of the renin-angiotensin axis in this group. However, it is not apparent whether such patients are more at risk of developing hypertension at a later time. |
| Databáze: | OpenAIRE |
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