Bromhexine Treatment of Sjögren's Syndrome: Effect on Lacrimal and Salivary Secretion, and on Proteins in Tear Fluid and Saliva
| Autor: | H. Isager, Jan Ulrik Prause, Rolf Manthorpe, L. Høj, K. Frost-Larsen |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male medicine.medical_specialty Saliva Immunology Placebo Random Allocation Rheumatology Internal medicine Humans Immunology and Allergy Medicine Tear secretion Salivary Proteins and Peptides Aged Clinical Trials as Topic biology business.industry Bromhexine Proteins General Medicine Middle Aged Sjogren's Syndrome Endocrinology Salivary secretion Immunoglobulin M Tears biology.protein Female sense organs Sjogren s business medicine.drug |
| Zdroj: | Scandinavian Journal of Rheumatology. 10:177-180 |
| ISSN: | 1502-7732 0300-9742 |
| DOI: | 10.3109/03009748109095294 |
| Popis: | In a randomized clinical study, 32 patients with Sögren's syndrome (SS were given placebo/bromhexine (Bisolvon) 48 mg daily for 3 weeks. Various ophthalmological and oral variables as well as different proteins in the tear fluid and saliva were registered. Bromhexine stimulated the tear secretion significantly, presumable without changing the protein composition of the tear fluid. In contrast to other proteins in saliva the IgM concentration decreased in patients with high pre-treatment values. Bromhexine may be of valuable help in the treatment of some patients with SS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|