General electrochemical Minisci alkylation of N-heteroarenes with alkyl halides

Autor: Roberto del Río-Rodríguez, Lorena Fragoso-Jarillo, Alberto F. Garrido-Castro, M. Carmen Maestro, Jose A. Fernández-Salas, José Alemán
Přispěvatelé: UAM. Departamento de Química Orgánica
Jazyk: angličtina
Rok vydání: 2022
Předmět:
DOI: 10.1039/d2sc01799g
Popis: Herein, we report, a general, facile and environmentally friendly Minisci-type alkylation of N-heteroarenes under simple and straightforward electrochemical conditions using widely available alkyl halides as radical precursors. Primary, secondary and tertiary alkyl radicals have been shown to be efficiently generated and coupled with a large variety of N-heteroarenes. The method presents a very high functional group tolerance, including various heterocyclic-based natural products, which highlights the robustness of the methodology. This applicability has been further proved in the synthesis of various interesting biologically valuable building blocks. In addition, we have proposed a mechanism based on different proofs and pieces of electrochemical evidence
Databáze: OpenAIRE