Relationship between thallium-201 kinetics and proliferative activity assessed by monoclonal antibody MIB-1 in brain tumours
| Autor: | Norihiko Kume, Akiko Hara, Kazuyoshi Suga, Y. Ishikawa, Naofumi Matsunaga, Kazumi Motoyama, Takafumi Nishizaki |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent medicine.drug_class chemistry.chemical_element Monoclonal antibody Central nervous system disease Pharmacokinetics medicine Humans Radiology Nuclear Medicine and imaging Child Radionuclide Imaging Aged Aged 80 and over biology Cell growth business.industry Brain Neoplasms Antibodies Monoclonal Infant General Medicine Middle Aged medicine.disease Staining Thallium Radioisotopes chemistry Child Preschool biology.protein Thallium Immunohistochemistry Female Antibody business Cell Division |
| Zdroj: | European journal of nuclear medicine. 28(10) |
| ISSN: | 0340-6997 |
| Popis: | To clarify the relationship between thallium-201 chloride kinetics and proliferative activity in brain tumours, a single-photon emission tomographic (SPET) study was performed and the results correlated with monoclonal antibody MIB-1 staining of the tumour tissue. 201Tl SPET was performed 10 min (early scan) and 2 h (delayed scan) after intravenous administration of 201Tl (111 MBq) in 34 intra-axial tumours including 24 malignant tumours, and in 27 extra-axial tumours including one malignant tumour. Tumour 201Tl kinetic parameters [early and delayed uptake ratios (ER and DR, respectively), retention index (RI), and the ratio of tumour delayed activity to early activity (Td/Te)] were compared with tumour tissue MIB-1 labelling indices (MIB-1 LI) representative of tumour cell proliferative activity. In the intra-axial tumours, ER and DR and MIB-1 LI were significantly higher in the malignant tumours than in the benign tumours. ER and DR were significantly correlated with MIB-1 LI (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink