Vitamin D Status and Clinical Outcomes in Acute Respiratory Distress Syndrome: A Secondary Analysis From the Assessment of Low Tidal Volume and Elevated End-Expiratory Volume to Obviate Lung Injury (ALVEOLI) Trial
| Autor: | Carlos A. Camargo, B. T. Thompson, Sadeq A. Quraishi, Ishir Bhan, Ednan K. Bajwa, Michael A. Matthay |
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| Rok vydání: | 2021 |
| Předmět: |
ARDS
medicine.medical_specialty medicine.medical_treatment Acute respiratory distress 030204 cardiovascular system & hematology Lung injury Critical Care and Intensive Care Medicine 03 medical and health sciences 0302 clinical medicine Secondary analysis Internal medicine Tidal Volume medicine Vitamin D and neurology Humans 030212 general & internal medicine Vitamin D Mechanical ventilation Respiratory Distress Syndrome business.industry Lung Injury medicine.disease Respiration Artificial Volume (thermodynamics) Low tidal volume Cardiology business |
| Zdroj: | Journal of Intensive Care Medicine. 37:793-802 |
| ISSN: | 1525-1489 0885-0666 |
| DOI: | 10.1177/08850666211028139 |
| Popis: | Background: Acute respiratory distress syndrome (ARDS) is a highly morbid condition that has limited therapeutic options. Optimal vitamin D status has been linked to immunological effects that may benefit critically ill patients. Therefore, we investigated whether admission 25-hydroxyvitamin D levels (25OHD) are associated with clinical outcomes in ARDS patients. Methods: We performed a secondary analysis of data from a randomized, controlled trial comparing oxygenation strategies in 549 patients with ARDS (NCT00000579). Baseline 25OHD was measured in stored plasma samples. We investigated the relationship between vitamin D status and ventilator-free days (VFD) as well as 90-day survival, using linear regression and Cox proportional hazard models, respectively. Analyses were adjusted for age, race, and Acute Physiology and Chronic Health Evaluation III score. Results: Baseline 25OHD was measured in 476 patients. 90% of these individuals had 25OHD 10 ng/ml. Conclusions: In patients with ARDS, vitamin D status is associated with duration of mechanical ventilation and 90-day mortality. Randomized, controlled trials are warranted to determine whether vitamin D supplementation improves clinical outcomes in ARDS patients. |
| Databáze: | OpenAIRE |
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